6-羟基-2-(4-甲氧基苯基)-4H-色烯-4-酮合成路线 （共 9 条）
反应条件
hydrogenchloride; lithium hydroxide; sulfuric acid in tetrahydrofuran; acetic acid
参考文献
Buchholz, Herwig; Perruchon, Sophie
Patent: US2004/59100 A1, 2004 ;
反应条件
potassium hydroxide in methanol; dichloromethane T=0 - 5°C; 3 h;
参考文献
Erickson, Ronald H.; Natalie, Kenneth J.; Bock, William; Lu, Zhijian; Farzin, Farzaneh; et al.
Journal of Medicinal Chemistry, 1992 , vol. 35, # 9 p. 1526 - 1535
反应条件
1: 20percent potassium hydroxide/H2O / ethanol / 0 °C 2: 100 mg / DDQ / benzene / 20 h / Heating View Scheme
参考文献
Erickson, Ronald H.; Natalie, Kenneth J.; Bock, William; Lu, Zhijian; Farzin, Farzaneh; et al.
Journal of Medicinal Chemistry, 1992 , vol. 35, # 9 p. 1526 - 1535
反应条件
1: NaH / dimethylformamide / 1.5 h / 0 - 5 °C 2: sulfuric acid / acetic acid / 1 h / Heating 3: KOH / methanol; CH2Cl2 / 3 h / 0 - 5 °C View Scheme
参考文献
Erickson, Ronald H.; Natalie, Kenneth J.; Bock, William; Lu, Zhijian; Farzin, Farzaneh; et al.
Journal of Medicinal Chemistry, 1992 , vol. 35, # 9 p. 1526 - 1535
反应条件
1: 90 percent / Br2 / CCl4 / Heating 2: toluene / Heating 3: 1.) 47percent HBr; 2.) aq.Na2CO3 / 1.) 100 deg C 4: 2.) 0.5N NaOH / 1.) pyridine, 3 h, 60 deg C; 2.) 50 deg C, 1 h View Scheme
参考文献
Le Floc'H, Yves; Lefeuvre, Martine
Tetrahedron Letters, 1986 , vol. 27, # 24 p. 2751 - 2752
反应条件
1: 20percent potassium hydroxide/H2O / ethanol / 0 °C 2: 100 mg / DDQ / benzene / 20 h / Heating View Scheme
参考文献
Singh, M.; Singh, J.
Zeitschrift fuer Naturforschung, Teil B: Anorganische Chemie, Organische Chemie, 1985 , vol. 40, # 4 p. 550 - 552
反应条件
sodium 4-methoxyphenylacetate T=180°C; Erwaermen des Reaktionsprodukts mit aethanol. Kalilauge;
参考文献
Chadha; Venkataraman
Journal of the Chemical Society, 1933 , p. 1073,1075
反应条件
1: 1.) 47percent HBr; 2.) aq.Na2CO3 / 1.) 100 deg C 2: 2.) 0.5N NaOH / 1.) pyridine, 3 h, 60 deg C; 2.) 50 deg C, 1 h View Scheme
参考文献
Le Floc'H, Yves; Lefeuvre, Martine
Tetrahedron Letters, 1986 , vol. 27, # 24 p. 2751 - 2752
反应条件
sodium hydroxide 1.) pyridine, 3 h, 60 deg C; 2.) 50 deg C, 1 h; Yield given. Multistep reaction;
参考文献
Le Floc'H, Yves; Lefeuvre, Martine
Tetrahedron Letters, 1986 , vol. 27, # 24 p. 2751 - 2752
