5-(6-氨基嘌呤-9-基)-3,4-二羟基四氢呋喃-2-甲酰胺合成路线 （共 7 条）
反应条件
trifluoroacetic acid T=0°C; 2 h;
参考文献
Wnuk, Stanislaw F.; Liu, Siming; Yuan, Chong-Sheng; Borchardt, Ronald T.; Robins, Morris J.
Journal of Medicinal Chemistry, 1996 , vol. 39, # 21 p. 4162 - 4166
反应条件
1: 1-[3-(dimethylamino)propyl]-3-ethylcarbodiimide*HCl / dimethylformamide / 3 h / 20 °C 2: NH3 / dimethylformamide / 1 h / 20 °C 3: 80percent aq. TFA / 20 °C View Scheme
参考文献
Umino; Yoshioka; Saitoh; Minakawa; Nakata; Matsuda
Journal of Medicinal Chemistry, 2001 , vol. 44, # 2 p. 208 - 214
反应条件
1: NH3 / dimethylformamide / 1 h / 20 °C 2: 80percent aq. TFA / 20 °C View Scheme
参考文献
Umino; Yoshioka; Saitoh; Minakawa; Nakata; Matsuda
Journal of Medicinal Chemistry, 2001 , vol. 44, # 2 p. 208 - 214
反应条件
1: 60 percent / CrO3, glacial acetic acid / 48 h / Ambient temperature 2: SOCl2, N,N-dimethylformamide / CHCl3 / 6 h / Heating 3: NH3 / CHCl3 / 0.33 h / 10 °C 4: NH3, (C2H5)3N / ethanol / 48 h / Heating 5: 1 N aq. HCl / 1 h / 60 °C View Scheme
参考文献
Olsson; Kusachi; Thompson; Ukena; Padgett; Daly
Journal of medicinal chemistry, 1986 , vol. 29, # 9 p. 1683 - 1689
反应条件
1: NH3 / CHCl3 / 0.33 h / 10 °C 2: NH3, (C2H5)3N / ethanol / 48 h / Heating 3: 1 N aq. HCl / 1 h / 60 °C View Scheme
参考文献
Olsson; Kusachi; Thompson; Ukena; Padgett; Daly
Journal of medicinal chemistry, 1986 , vol. 29, # 9 p. 1683 - 1689
反应条件
1: NH3, (C2H5)3N / ethanol / 48 h / Heating 2: 1 N aq. HCl / 1 h / 60 °C View Scheme
参考文献
Olsson; Kusachi; Thompson; Ukena; Padgett; Daly
Journal of medicinal chemistry, 1986 , vol. 29, # 9 p. 1683 - 1689
反应条件
1: 55 percent / liq. NH2 / 2 h 2: 1 N aq. HCl / 0.75 h / 60 - 70 °C View Scheme
参考文献
Prasad, Raj Nandan; Bariana, Dilbagh S.; Fung, Anthony; Savic, Milica; Tietje, Karin; et al.
Journal of Medicinal Chemistry, 1980 , vol. 23, # 3 p. 313 - 319
