1: With sodium hydroxide in methanol T=20°C; 24 h; 2: With hydrogenchloride in methanol; water pH=~ 1;

water T=180 - 215°C; 4 - 16 h; Product distribution / selectivity;

sodium chlorite; sodium dihydrogenphosphate in water; acetonitrile T=20°C; 24 h;

1: 83 percent 2: 87 percent / PPh3 / Pd(OAc)2 / various solvent(s) / 3 h / Heating 3: 88 percent / NaI / hexamethylphosphoric acid triamide / 100 °C 4: 9-BBN 5: CrO3 View Scheme

1: 87 percent / PPh3 / Pd(OAc)2 / various solvent(s) / 3 h / Heating 2: 88 percent / NaI / hexamethylphosphoric acid triamide / 100 °C 3: 9-BBN 4: CrO3 View Scheme

1: 83 percent 2: 87 percent / PPh3 / Pd(OAc)2 / various solvent(s) / 3 h / Heating 3: 88 percent / NaI / hexamethylphosphoric acid triamide / 100 °C 4: 9-BBN 5: CrO3 View Scheme

1.1: LiCl; CuI / diethyl ether; tetrahydrofuran / 0.08 h / -80 °C 1.2: diethyl ether; tetrahydrofuran / 1 h / -80 - -30 °C 1.3: 70 percent / 2-(methyliminomethyl)phenol / diethyl ether; tetrahydrofuran / -80 - 20 °C 2.1: O3 / CH2Cl2 / 0.25 h / -80 °C 2.2: 70 percent / Me2S / CH2Cl2 / -80 - 20 °C 3.1: NaH2PO4*H2O; 30percent H2O2; NaClO2 / H2O; acetonitrile / 24 h / 20 °C View Scheme

1: HCl / acetic acid 2: TsOH 3: (i) Br2, CaCO3, (ii) LiBr, Li2CO3 5: aq. NaOH View Scheme

1: (i) NaH, (ii) /BRN= 1730981/ 2: HCl / acetic acid 3: TsOH 4: (i) Br2, CaCO3, (ii) LiBr, Li2CO3 6: aq. NaOH View Scheme

1: 88 percent / NaI / hexamethylphosphoric acid triamide / 100 °C 2: 9-BBN 3: CrO3 View Scheme