(S)-3-羟基十四烷酸合成路线 （共 28 条）
反应条件
1: 87 percent / L-Selectride / tetrahydrofuran / 1 h / -10 °C 2: hexamethylphosphoric acid triamide / 1 h / 110 °C 3: Bu3SnH, AIBN / toluene / 1 h / 60 °C View Scheme
参考文献
Journal of Organic Chemistry, , vol. 59, # 24 p. 7383 - 7394
反应条件
1: 60 percent / pyridine / tetrahydrofuran / 1.) -30 deg C, 1 h, 2.) 0 deg C, 16 h 2: LiBr / acetone / 2 h / Heating 3: tetrahydrofuran / Heating 4: LDA / tetrahydrofuran / -78 °C 5: Li(sec-Bu)3BH / tetrahydrofuran / -10 °C 6: hexamethylphosphoric acid triamide / 1 h / 110 °C 7: Bu3SnH, AIBN / toluene / 1 h / 60 °C View Scheme
参考文献
Journal of Organic Chemistry, , vol. 59, # 24 p. 7383 - 7394
反应条件
1: tetrahydrofuran / Heating 2: LDA / tetrahydrofuran / -78 °C 3: Li(sec-Bu)3BH / tetrahydrofuran / -10 °C 4: hexamethylphosphoric acid triamide / 1 h / 110 °C 5: Bu3SnH, AIBN / toluene / 1 h / 60 °C View Scheme
参考文献
Journal of Organic Chemistry, , vol. 59, # 24 p. 7383 - 7394
反应条件
1: aq. HOAc / tetrahydrofuran / 1.5 h 2: 60 percent / pyridine / tetrahydrofuran / 1.) -30 deg C, 1 h, 2.) 0 deg C, 16 h 3: LiBr / acetone / 2 h / Heating 4: tetrahydrofuran / Heating 5: LDA / tetrahydrofuran / -78 °C 6: Li(sec-Bu)3BH / tetrahydrofuran / -10 °C 7: hexamethylphosphoric acid triamide / 1 h / 110 °C 8: Bu3SnH, AIBN / toluene / 1 h / 60 °C View Scheme
参考文献
Journal of Organic Chemistry, , vol. 59, # 24 p. 7383 - 7394
反应条件
1: LiBr / acetone / 2 h / Heating 2: tetrahydrofuran / Heating 3: LDA / tetrahydrofuran / -78 °C 4: Li(sec-Bu)3BH / tetrahydrofuran / -10 °C 5: hexamethylphosphoric acid triamide / 1 h / 110 °C 6: Bu3SnH, AIBN / toluene / 1 h / 60 °C View Scheme
参考文献
Journal of Organic Chemistry, , vol. 59, # 24 p. 7383 - 7394
反应条件
1: hexamethylphosphoric acid triamide / 1 h / 110 °C 2: Bu3SnH, AIBN / toluene / 1 h / 60 °C View Scheme
参考文献
Journal of Organic Chemistry, , vol. 59, # 24 p. 7383 - 7394
反应条件
1: Li(sec-Bu)3BH / tetrahydrofuran / -10 °C 2: hexamethylphosphoric acid triamide / 1 h / 110 °C 3: Bu3SnH, AIBN / toluene / 1 h / 60 °C View Scheme
参考文献
Journal of Organic Chemistry, , vol. 59, # 24 p. 7383 - 7394
反应条件
Porcine Pancreas Lipase; water in aq. phosphate buffer T=36°C; pH=7.6; 7 h; Resolution of racemate; enantioselective reaction;
参考文献
Monatshefte fur Chemie, , vol. 144, # 7 p. 1087 - 1091
反应条件
potassium permanganate; sodium periodate in water; tert-butyl alcohol
参考文献
Journal of Antibiotics, , vol. 31, # 8 p. 797 - 800
反应条件
sodium hydroxide; dihydrogen peroxide in methanol Hydrolysis; 10 h; Heating;
参考文献
Tetrahedron Asymmetry, , vol. 10, # 15 p. 2945 - 2950
