3-氯喹噁啉-2(1h)-酮合成路线 （共 9 条）
反应条件
trichlorophosphate in dichloromethane T=20°C; 12 h;
参考文献
Galal, Shadia A.; Abdelsamie, Ahmed S.; Tokuda, Harukuni; Suzuki, Nobutaka; Lida, Akira; Elhefnawi, Mahmoud M.; Ramadan, Raghda A.; Atta, Mona H.E.; El Diwani, Hoda I.
European Journal of Medicinal Chemistry, 2011 , vol. 46, # 1 p. 327 - 340
反应条件
water; lithium hydroxide hydrate in tetrahydrofuran T=65°C; 24 h; chemoselective reaction;
参考文献
Yang, Yanchun; Zhang, Shuzhen; Wu, Bobin; Ma, Mingming; Chen, Xin; Qin, Xiangyu; He, Minlan; Hussain, Saghir; Jing, Chaojun; Ma, Bing; Zhu, Changjin
ChemMedChem, 2012 , vol. 7, # 5 p. 823 - 835
反应条件
1: various solvent(s) / 1 h / 130 °C 2: SOCl2 / toluene; dimethylformamide / 2 h / 130 °C View Scheme
参考文献
Galal, Shadia A.; Abdelsamie, Ahmed S.; Soliman, Salwa M.; Mortier, Jeremie; Wolber, Gerhard; Ali, Mamdouh M.; Tokuda, Harukuni; Suzuki, Nobutaka; Lida, Akira; Ramadan, Raghda A.; El Diwani, Hoda I.
European Journal of Medicinal Chemistry, 2013 , vol. 69, p. 115 - 124
反应条件
phosphorus pentachloride T=220 - 240°C; 30 h;
参考文献
Singh, Harjit; Aggarwal, Sunil K.; Malhotra, Nageshwar
Synthesis, 1983 , # 10 p. 791 - 793
反应条件
hydrazine hydrate in ethanol T=20°C; 0.5 h;
参考文献
Galal, Shadia A.; Abdelsamie, Ahmed S.; Soliman, Salwa M.; Mortier, Jeremie; Wolber, Gerhard; Ali, Mamdouh M.; Tokuda, Harukuni; Suzuki, Nobutaka; Lida, Akira; Ramadan, Raghda A.; El Diwani, Hoda I.
European Journal of Medicinal Chemistry, 2013 , vol. 69, p. 115 - 124
反应条件
ammonia in ethanol T=0 - 5°C; 8 h;
参考文献
Galal, Shadia A.; Abdelsamie, Ahmed S.; Tokuda, Harukuni; Suzuki, Nobutaka; Lida, Akira; Elhefnawi, Mahmoud M.; Ramadan, Raghda A.; Atta, Mona H.E.; El Diwani, Hoda I.
European Journal of Medicinal Chemistry, 2011 , vol. 46, # 1 p. 327 - 340
反应条件
water 7 h; Heating; Yield given;
参考文献
Singh, Harjit; Aggarwal, Sunil K.; Malhotra, Nageshwar
Synthesis, 1983 , # 10 p. 791 - 793
反应条件
1: With trichlorophosphate in N,N-dimethyl-formamide T=50°C; 4 h; 2: With ammonia in water Cooling with ice;
参考文献
Galal, Shadia A.; Abdelsamie, Ahmed S.; Tokuda, Harukuni; Suzuki, Nobutaka; Lida, Akira; Elhefnawi, Mahmoud M.; Ramadan, Raghda A.; Atta, Mona H.E.; El Diwani, Hoda I.
European Journal of Medicinal Chemistry, 2011 , vol. 46, # 1 p. 327 - 340
反应条件
1: acetonitrile / 2 h / 120 °C
2: various solvent(s) / 0.42 h / 220 - 230 °C
3: pyridine / 3 h / 100 °C
View Scheme
参考文献
Loev; Musser; Brown; Jones; Kahen; Huang; Khandwala; Sonnino-Goldman; Leibowitz
Journal of Medicinal Chemistry, 1985 , vol. 28, # 3 p. 363 - 366
