乙基2-[[(2S)-3-(4-羟基苯基)-2-[[2-(苯基甲氧羰基氨基)乙酰基]氨基]丙酰]氨基]乙酸酯合成路线 （共 8 条）
反应条件
1: 80 percent / HCl 2: 86 percent / DCC, HOBt / dimethylformamide / 24 h / 0 - 20 °C 3: 87 percent / NaOH / ethanol; H2O 4: 84 percent / DCC, HOBt / dimethylformamide / 36 h / 0 - 20 °C 5: 1) H2O2, acetone - H2O, 25 degC, 2 min, pH 9, 2) NaHSO3 View Scheme
参考文献
Roberts, David C.; Suda, Kohji; Samanen, James; Kemp, D. S.
Tetrahedron Letters, 1980 , vol. 21, p. 3435 - 3438
反应条件
1: 84 percent / DCC, HOBt / dimethylformamide / 36 h / 0 - 20 °C 2: 1) H2O2, acetone - H2O, 25 degC, 2 min, pH 9, 2) NaHSO3 View Scheme
参考文献
Roberts, David C.; Suda, Kohji; Samanen, James; Kemp, D. S.
Tetrahedron Letters, 1980 , vol. 21, p. 3435 - 3438
反应条件
1: 87 percent / NaOH / ethanol; H2O 2: 84 percent / DCC, HOBt / dimethylformamide / 36 h / 0 - 20 °C 3: 1) H2O2, acetone - H2O, 25 degC, 2 min, pH 9, 2) NaHSO3 View Scheme
参考文献
Roberts, David C.; Suda, Kohji; Samanen, James; Kemp, D. S.
Tetrahedron Letters, 1980 , vol. 21, p. 3435 - 3438
反应条件
1: 86 percent / DCC, HOBt / dimethylformamide / 24 h / 0 - 20 °C 2: 87 percent / NaOH / ethanol; H2O 3: 84 percent / DCC, HOBt / dimethylformamide / 36 h / 0 - 20 °C 4: 1) H2O2, acetone - H2O, 25 degC, 2 min, pH 9, 2) NaHSO3 View Scheme
参考文献
Roberts, David C.; Suda, Kohji; Samanen, James; Kemp, D. S.
Tetrahedron Letters, 1980 , vol. 21, p. 3435 - 3438
反应条件
1: 86 percent / DCC, HOBt / dimethylformamide / 24 h / 0 - 20 °C 2: 87 percent / NaOH / ethanol; H2O 3: 84 percent / DCC, HOBt / dimethylformamide / 36 h / 0 - 20 °C 4: 1) H2O2, acetone - H2O, 25 degC, 2 min, pH 9, 2) NaHSO3 View Scheme
参考文献
Roberts, David C.; Suda, Kohji; Samanen, James; Kemp, D. S.
Tetrahedron Letters, 1980 , vol. 21, p. 3435 - 3438
反应条件
1: ethanol; hydrazine hydrate 2: aqueous hydrochloric acid; sodium nitrite View Scheme
参考文献
Posternak; Grafl
Helvetica Chimica Acta, 1945 , vol. 28, p. 1258,1266
反应条件
hydrogenchloride; sodium nitrite
参考文献
Posternak; Grafl
Helvetica Chimica Acta, 1945 , vol. 28, p. 1258,1266
反应条件
1) H2O2, acetone - H2O, 25 degC, 2 min, pH 9, 2) NaHSO3; Yield given. Multistep reaction;
参考文献
Roberts, David C.; Suda, Kohji; Samanen, James; Kemp, D. S.
Tetrahedron Letters, 1980 , vol. 21, p. 3435 - 3438
