sodium methylate in methanol T=0 - 20°C;

<b>With</b>&nbsp; <a href="#" onclick="return RXDsubstances(event, this, '3587193', constants.ctx, '0')">bromine</a>&nbsp;<b>in</b>&nbsp; <a href="#" onclick="return RXDsubstances(event, this, '1730800', constants.ctx, '0')">dichloromethane</a> <br />T=-78&deg;C;&nbsp;0.0833333&nbsp;h;&nbsp;<br /> &nbsp;

<b>Multi-step reaction with 3 steps<br /> </b>1.1: butyllithium / diethyl ether; hexane / 1.5 h / -78 &deg;C<br />1.2: 87 percent / diethyl ether; hexane / -78 - 20 &deg;C<br />2.1: 93 percent / Et₃N; tri-2-furylphosphine / Pd₂(dba)3*CHCl₃ / tetrahydrofuran / 24 h / 50 &deg;C<br />3.1: Br₂ / CH₂Cl₂ / 0.08 h / -78 &deg;C<br /> <br /> &nbsp;

<b>Multi-step reaction with 2 steps<br /> </b>1: 93 percent / Et₃N; tri-2-furylphosphine / Pd₂(dba)3*CHCl₃ / tetrahydrofuran / 24 h / 50 &deg;C<br />2: Br₂ / CH₂Cl₂ / 0.08 h / -78 &deg;C<br /> <br /> &nbsp;