1-甲基-2-苯基吲哚合成路线 （共 124 条）
反应条件
[Pd(η3-1-Ph-allyl)(μ-Cl)]2; C35H55OPSi; potassium tert-butylate in toluene T=90°C; Buchwald-Hartwig Coupling; 12 h; Inert atmosphereSealed tube; Reagent/catalyst;
参考文献
DALHOUSIE UNIVERSITY; STRADIOTTO, Mark John
Patent: WO2013/159229 A1, 2013 ;
Location in patent: Paragraph 00206-00208 ;
反应条件
oxygen; acetic acid; palladium diacetate T=20°C; P=760.051 Torr;
参考文献
Yang, Shang-Dong; Sun, Chang-Liang; Fang, Zhao; Li, Bi-Jie; Li, Yi-Zhou; Shi, Zhang-Jie
Angewandte Chemie - International Edition, 2008 , vol. 47, # 8 p. 1473 - 1476
反应条件
potassium phosphate; tetrakis(triphenylphosphine) palladium(0) in 1,4-dioxane; water T=90°C; Suzuki-Miyaura Coupling; 6 h;
参考文献
Ibad, Muhammad Farooq; Zinad, Dhafer Saber; Hussain, Munawar; Ali, Asad; Villinger, Alexander; Langer, Peter
Tetrahedron, 2013 , vol. 69, # 35 p. 7492 - 7504
反应条件
1: 2-phenyl-1H-indole With sodium hydride in N,N-dimethyl-formamide; mineral oil T=0°C; 1 h; 2: methyl iodide in N,N-dimethyl-formamide; mineral oil T=0 - 20°C;
参考文献
Yu, Xufen; Park, Eun-Jung; Kondratyuk, Tamara P.; Pezzuto, John M.; Sun, Dianqing
Organic and Biomolecular Chemistry, 2012 , vol. 10, # 44 p. 8835 - 8847
反应条件
palladium(II) complex with imidazolyl carbene ligand; caesium acetate in N,N-dimethyl acetamide T=125°C; 24 h;
参考文献
Toure, B. Barry; Lane, Benjamin S.; Sames, Dalibor
Organic Letters, 2006 , vol. 8, # 10 p. 1979 - 1982
反应条件
potassium phosphate; palladium bis(2,2,6,6-tetramethyl-3,5-heptanedionate) in 1-methyl-pyrrolidin-2-one T=125°C; 36 h;
参考文献
Nandurkar, Nitin S.; Bhanushali, Mayur J.; Bhor, Malhari D.; Bhanage, Bhalchandra M.
Tetrahedron Letters, 2008 , vol. 49, # 6 p. 1045 - 1048
反应条件
C20H15BrN2Pd; potassium acetate T=80°C; 24 h; Reagent/catalystSolventTime; Overall yield = 98 percentChromat.; regioselective reaction;
参考文献
Feng, Jie; Lu, Guoping; Lv, Meifang; Cai, Chun
Journal of Organometallic Chemistry, 2014 , vol. 761, p. 28 - 31
反应条件
1: iodobenzene With tris(dibenzylideneacetone)dipalladium(0) chloroform complex; copper(l) iodide; sodium t-butanolate in toluene 0.166667 h; 2: 2-(hydroxydimethylsilyl)-1-methyl-1H-indole in toluene T=20°C; 3 h;
参考文献
Denmark, Scott E.; Baird, John D.; Regens, Christopher S.
Journal of Organic Chemistry, 2008 , vol. 73, # 4 p. 1440 - 1455
反应条件
cobalt/rhodium in tetrahydrofuran T=90°C; P=15201 Torr; 5 h;
参考文献
Park, Ji Hoon; Kim, Eunha; Chung, Young Keun
Organic Letters, 2008 , vol. 10, # 21 p. 4718 - 4721
反应条件
Pd2[(C6H4)PPh2]2[CF3C(O)CHC(O)CF3]2 in acetic acid T=24.84°C; 30 h; Inert atmosphereSchlenk technique; Reagent/catalystTimeSolvent;
参考文献
Ibanez, Susana; Estevan, Francisco; Hirva, Pipsa; Sanau, Mercedes; Ubeda, Ma. Angeles
Organometallics, 2012 , vol. 31, # 23 p. 8098 - 8108
