1-[(4-甲基苯基)磺酰基]-1,5,6,7-四氢-4H-吲哚-4-酮合成路线 （共 10 条）
参考文献
Rosenberg, Marianne Lenes; Aasheim, Jens H. F.; Trebbin, Martin; Uggerud, Einar; Hansen, Tore
Tetrahedron Letters, 2009 , vol. 50, # 47 p. 6506 - 6508
反应条件
1: 1,5,6,7-tetrahydro-4H-indol-4-one With sodium hydride in N,N-dimethyl-formamide T=0°C; 0.5 h; Inert atmosphere; 2: toluene-4-sulfonic acid in N,N-dimethyl-formamide Inert atmosphere;
参考文献
Rosenberg, Marianne Lenes; Aasheim, Jens H. F.; Trebbin, Martin; Uggerud, Einar; Hansen, Tore
Tetrahedron Letters, 2009 , vol. 50, # 47 p. 6506 - 6508
反应条件
N-ethyl-N,N-diisopropylamine in tetrahydrofuran; ethyl acetate
参考文献
Sugen, Inc.
Patent: US2003/69297 A1, 2003 ;
反应条件
N,N-dioctyl-1-octylamine; bromine; tin(IV) chloride in 1,2-dichloro-ethane T=-17 - 25°C; 3.25 h;
参考文献
Sakai, Makiko
Heterocycles, 1982 , vol. 19, # 7 p. 1269 - 1275
反应条件
ammonium hydroxide Yield given. Multistep reaction;
参考文献
Doi, Kazuyuki; Mori, Miwako
Heterocycles, 1996 , vol. 42, # 1 p. 113 - 116
反应条件
1: 1.) butyllithium / 1.) THF, -78 deg C, 2h; 2.) from -78 deg C to 0 deg C, 4 h 2: 81.1 percent / CuCl2 / aq. acetic acid / 5 h / Heating View Scheme
参考文献
Hatanaka, Naoto; Ozaki, Osamu; Matsumoto, Masakatsu
Tetrahedron Letters, 1986 , vol. 27, # 27 p. 3169 - 3172
反应条件
1: 1.) Bu-Li / 1.) THF, hexane, -78 deg C, 1 h, 2.) THF, hexane, a)-78 deg C, 2 h, b) RT, 2 h 2: 59 percent / CuCl2 / 1 h / Heating 3: 71 percent / NaOH / methanol / Heating View Scheme
参考文献
Hatanaka, Naoto; Watanabe, Nobuko; Matsumoto, Masakatsu
Heterocycles, 1986 , vol. 24, # 7 p. 1987 - 1996
反应条件
copper(ll) bromide in ethyl acetate
0.75 h; Heatingvar. solvents; Product distribution;
参考文献
Matsumoto, Masakatsu; Ishida, Yasuko; Watanabe, Nobuko
Heterocycles, 1985 , vol. 23, # 1 p. 165 - 170
反应条件
1: 86 percent / CuCl2, 50percent aq. AcOH / 3.5 h / Heating
2: 98 percent / LiBr, Li2CO3 / dimethylformamide / 3 h / 150 °C
View Scheme
参考文献
Matsumoto, Masakatsu; Ishida, Yasuko; Watanabe, Nobuko
Heterocycles, 1985 , vol. 23, # 1 p. 165 - 170
反应条件
1: 1.) BuLi / 1.) THF, hexane, -78 deg C, 1.5 h, 2.) THF, hexane, from -78 deg C to RT
2: 80.8 percent / TsOH*H2O / CH2Cl2 / Ambient temperature
3: 53.8 percent / CuCl2 / methanol; tetrahydrofuran; H2O / 50 - 60 °C
View Scheme
参考文献
Hatanaka, Naoto; Watanabe, Nobuko; Matsumoto, Masakatsu
Heterocycles, 1986 , vol. 24, # 7 p. 1987 - 1996
