3-氯-1,1-二乙氧基丙烷合成路线 （共 57 条）
反应条件
water; naphthalenyllithium 1.) THF, -78 deg C, 6 h, 2.) 20 deg C, 2 h; Yield given. Multistep reaction. Title compound not separated from byproducts;
参考文献
Barluenga, Jose; Fernandez, Jose R.; Rubiera, Covadonga; Yus, Miguel
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1988 , p. 3113 - 3118
参考文献
Schuda, Paul Francis; Phillips, Jennifer L.
Journal of Heterocyclic Chemistry, 1984 , vol. 21, p. 669 - 672
参考文献
Chemische Berichte, , vol. 77/79, p. 617,626
反应条件
ethanol; ammonia T=115 - 118°C;
参考文献
Chemische Berichte, , vol. 34, p. 1917
参考文献
Rothstein
Journal of the Chemical Society, 1940 , p. 1563
反应条件
boron trifluoride diethyl etherate; water; naphthalenyllithium; 3-chloro-benzenecarboperoxoic acid 1.) THF, -78 deg C, 6 h, 2.) 20 deg C, 2 h, 3.) CH2Cl2; Yield given. Multistep reaction;
参考文献
Barluenga, Jose; Fernandez, Jose R.; Rubiera, Covadonga; Yus, Miguel
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1988 , p. 3113 - 3118
反应条件
1: 3-chloro-propionaldehyde diethyl acetal With lithium; 4,4'-di-tert-butylbiphenyl in tetrahydrofuran T=-78°C; 1 h; 2: With zinc dibromide in tetrahydrofuran T=-78 - 20°C; 3: bromobenzene With Pd(OAc)2(PPh3)2 in tetrahydrofuran T=70°C; Negishi cross-coupling reaction; Further stages.;
参考文献
European Journal of Organic Chemistry, , # 12 p. 1989 - 1995
反应条件
in 1-methyl-pyrrolidin-2-one
参考文献
Ortho Pharmaceutical Corporation
Patent: US5171754 A1, 1992 ;
反应条件
in N,N-dimethyl-formamide T=145°C; 5 h;
参考文献
Carroll; Berrang; Linn
Journal of Heterocyclic Chemistry, 1981 , vol. 18, # 5 p. 941 - 946
参考文献
Wohl
Chemische Berichte, 1898 , vol. 31, p. 1799
