1: 63 percent / DIBAL-H / CH2Cl2 / -78 °C 2: 74 percent / MnO2 / CH2Cl2 3: 55 percent / tetrahydrofuran / 0.5 h / 0 °C 4: 79 percent / MnO2 / CH2Cl2 / Ambient temperature 5: 1.) NaH / 1.) THF, 2.) THF, RT 6: 5N aq. KOH / methanol / 1 h / 60 °C View Scheme
参考文献
Tadikonda, Praveen K.; Lacy, James M.; Rigdon, Michael G.; Deluca, Hector F.
Journal of Labelled Compounds and Radiopharmaceuticals, 1997 , vol. 39, # 1 p. 1 - 10
1: 68 percent / LAH / tetrahydrofuran / Ambient temperature 2: 79 percent / MnO2 / CH2Cl2 / Ambient temperature 3: 75 percent / benzene 4: 69 percent / 80percent aq. HCOOH / hexane / Ambient temperature 5: 63 percent / DIBAL-H / CH2Cl2 / -78 °C 6: 74 percent / MnO2 / CH2Cl2 7: 55 percent / tetrahydrofuran / 0.5 h / 0 °C 8: 79 percent / MnO2 / CH2Cl2 / Ambient temperature 9: 1.) NaH / 1.) THF, 2.) THF, RT 10: 5N aq. KOH / methanol / 1 h / 60 °C View Scheme
参考文献
Tadikonda, Praveen K.; Lacy, James M.; Rigdon, Michael G.; Deluca, Hector F.
Journal of Labelled Compounds and Radiopharmaceuticals, 1997 , vol. 39, # 1 p. 1 - 10
1: 75 percent / benzene 2: 69 percent / 80percent aq. HCOOH / hexane / Ambient temperature 3: 63 percent / DIBAL-H / CH2Cl2 / -78 °C 4: 74 percent / MnO2 / CH2Cl2 5: 55 percent / tetrahydrofuran / 0.5 h / 0 °C 6: 79 percent / MnO2 / CH2Cl2 / Ambient temperature 7: 1.) NaH / 1.) THF, 2.) THF, RT 8: 5N aq. KOH / methanol / 1 h / 60 °C View Scheme
参考文献
Tadikonda, Praveen K.; Lacy, James M.; Rigdon, Michael G.; Deluca, Hector F.
Journal of Labelled Compounds and Radiopharmaceuticals, 1997 , vol. 39, # 1 p. 1 - 10
1: 79 percent / MnO2 / CH2Cl2 / Ambient temperature 2: 1.) NaH / 1.) THF, 2.) THF, RT 3: 5N aq. KOH / methanol / 1 h / 60 °C View Scheme
参考文献
Tadikonda, Praveen K.; Lacy, James M.; Rigdon, Michael G.; Deluca, Hector F.
Journal of Labelled Compounds and Radiopharmaceuticals, 1997 , vol. 39, # 1 p. 1 - 10
1: 69 percent / 80percent aq. HCOOH / hexane / Ambient temperature 2: 63 percent / DIBAL-H / CH2Cl2 / -78 °C 3: 74 percent / MnO2 / CH2Cl2 4: 55 percent / tetrahydrofuran / 0.5 h / 0 °C 5: 79 percent / MnO2 / CH2Cl2 / Ambient temperature 6: 1.) NaH / 1.) THF, 2.) THF, RT 7: 5N aq. KOH / methanol / 1 h / 60 °C View Scheme
参考文献
Tadikonda, Praveen K.; Lacy, James M.; Rigdon, Michael G.; Deluca, Hector F.
Journal of Labelled Compounds and Radiopharmaceuticals, 1997 , vol. 39, # 1 p. 1 - 10
Boehm, Marcus F.; McClurg, Michael R.; Pathirana, Charles; Mangelsdorf, David; White, Steven K.; et al.
Journal of Medicinal Chemistry, 1994 , vol. 37, # 3 p. 408 - 414
