1: 1.) NaH / 1.) THF, 2.) THF, RT 2: 5N aq. KOH / methanol / 1 h / 60 °C View Scheme
参考文献
Tadikonda, Praveen K.; Lacy, James M.; Rigdon, Michael G.; Deluca, Hector F.
Journal of Labelled Compounds and Radiopharmaceuticals, 1997 , vol. 39, # 1 p. 1 - 10
1: 55 percent / tetrahydrofuran / 0.5 h / 0 °C 2: 79 percent / MnO2 / CH2Cl2 / Ambient temperature 3: 1.) NaH / 1.) THF, 2.) THF, RT 4: 5N aq. KOH / methanol / 1 h / 60 °C View Scheme
参考文献
Tadikonda, Praveen K.; Lacy, James M.; Rigdon, Michael G.; Deluca, Hector F.
Journal of Labelled Compounds and Radiopharmaceuticals, 1997 , vol. 39, # 1 p. 1 - 10
1: 79 percent / MnO2 / CH2Cl2 / Ambient temperature 2: 75 percent / benzene 3: 69 percent / 80percent aq. HCOOH / hexane / Ambient temperature 4: 63 percent / DIBAL-H / CH2Cl2 / -78 °C 5: 74 percent / MnO2 / CH2Cl2 6: 55 percent / tetrahydrofuran / 0.5 h / 0 °C 7: 79 percent / MnO2 / CH2Cl2 / Ambient temperature 8: 1.) NaH / 1.) THF, 2.) THF, RT 9: 5N aq. KOH / methanol / 1 h / 60 °C View Scheme
参考文献
Tadikonda, Praveen K.; Lacy, James M.; Rigdon, Michael G.; Deluca, Hector F.
Journal of Labelled Compounds and Radiopharmaceuticals, 1997 , vol. 39, # 1 p. 1 - 10
1: 74 percent / MnO2 / CH2Cl2 2: 55 percent / tetrahydrofuran / 0.5 h / 0 °C 3: 79 percent / MnO2 / CH2Cl2 / Ambient temperature 4: 1.) NaH / 1.) THF, 2.) THF, RT 5: 5N aq. KOH / methanol / 1 h / 60 °C View Scheme
参考文献
Tadikonda, Praveen K.; Lacy, James M.; Rigdon, Michael G.; Deluca, Hector F.
Journal of Labelled Compounds and Radiopharmaceuticals, 1997 , vol. 39, # 1 p. 1 - 10
