1-甲基-2-吡咯烷甲醇合成路线 (共 10 条)
反应条件
hydrogen; palladium 10 on activated carbon in water 18 h;
参考文献
MEDICAL RESEARCH COUNCIL TECHNOLOGY; OSBORNE, Simon; CHAPMAN, Timothy; WALLACE, Claire
Patent: WO2012/127212 A1, 2012 ;
Location in patent: Page/Page column 101 ;
WO 2012/127212 A1
反应条件
sodium hydrogencarbonate; toluene-4-sulfonic acid in benzene
反应条件
1: With diisobutylaluminium hydride in dichloromethane 6 h; 2: With methanol in dichloromethane
参考文献
SHANGHAI HENGRUI PHARMACEUTICAL CO., LTD.; JIANGSU HENGRUI MEDICINE CO., LTD.
Patent: US2012/165352 A1, 2012 ;
Location in patent: Page/Page column 30-31 ;
反应条件
n-butyllithium in tetrahydrofuran; water
反应条件
in tetrahydrofuran; tetrahydrofuran.A; water
参考文献
Journal of the American Chemical Society, , vol. 61, p. 1195,1196
反应条件
1: sodium cyanoborohydride / methanol / 26 h / 0 - 20 °C 2: diisobutylaluminium hydride / dichloromethane / 6 h View Scheme
反应条件
1: thionyl chloride / 24 h / 20 °C / Cooling with ice 2: sodium cyanoborohydride / methanol / 26 h / 0 - 20 °C 3: diisobutylaluminium hydride / dichloromethane / 6 h View Scheme
参考文献
Journal of the Chemical Society, , p. 4458,4462