4-[(二甲基氨基)甲基]苯甲腈合成路线 （共 12 条）
反应条件
polymethylhydrosiloxane; HPtCl6·6H2O in tetrahydrofuran T=70°C; 4 h; Inert atmosphere; chemoselective reaction;
参考文献
Hanada, Shiori; Tsutsumi, Emi; Motoyama, Yukihiro; Nagashima, Hideo
Journal of the American Chemical Society, 2009 , vol. 131, # 41 p. 15032 - 15040
反应条件
in diethyl ether; water T=20°C;
参考文献
Tayama, Eiji; Kimura, Hiroshi
Angewandte Chemie - International Edition, 2007 , vol. 46, # 46 p. 8869 - 8871
反应条件
in diethyl ether T=-5 - 20°C; 22 h;
参考文献
Boehringer Ingelheim Pharma GmbH and Co.KG
Patent: EP1206446 B1, 2004 ;
Location in patent: Page 18-19 ;
反应条件
1: With titanium(IV) isopropylate in methanol T=20°C; Addition; 2: With sodium tetrahydroborate in methanol T=20°C; Reduction; 1.5 h;
参考文献
Bhattacharyya, Sukanta
Synthetic Communications, 2000 , vol. 30, # 11 p. 2001 - 2008
反应条件
1: 52 percent / N-bromosuccinimide, dibenzoyl peroxide / CCl4 / 7 h / Heating 2: 81 percent / diethyl ether View Scheme
参考文献
Norman,J.J. et al.
Canadian Journal of Chemistry, 1962 , vol. 40, p. 1547 - 1553
参考文献
Cohen,S.G.; Stein,N.M.
Journal of the American Chemical Society, 1971 , vol. 93, p. 6542 - 6551
反应条件
titanium(IV) isopropylate; sodium tetrahydroborate; triethylamine 1.) EtOH, 25 deg C, 10 h, 2.) 25 deg C, 10 h; Yield given. Multistep reaction;
参考文献
Bhattacharyya, Sukanta
Journal of Organic Chemistry, 1995 , vol. 60, # 15 p. 4928 - 4929
反应条件
Behandeln der Diazoverbindung mit Kupfercyanuer;
参考文献
Friedlaender; Mosczyc
Chemische Berichte, 1895 , vol. 28, p. 1141
反应条件
hydrogenchloride in tetrahydrofuran; methanol
参考文献
Agouron Pharmaceuticals, Inc.
Patent: US6218426 B1, 2001 ;
反应条件
iodosylbenzene; 5,10,15,20-tetrakisphenylporphyrinatoiron(III) chloride in benzene
参考文献
Smith, John R. Lindsay; Mortimer, David N.
Journal of the Chemical Society, Chemical Communications, 1985 , # 2 p. 64 - 65
