4-(氯甲基)-2-甲氧基吡啶合成路线 （共 5 条）
反应条件
thionyl chloride in dichloromethane T=20°C; 2 h;
参考文献
MERCK SHARP and DOHME CORP.; KUDUK, Scott, D.; SCHLEGEL, Kelly-Ann; YANG, Zhi-Qiang
Patent: WO2011/84368 A1, 2011 ;
Location in patent: Page/Page column 73 ;
WO 2011/084368 A1
反应条件
1: 1,4-dioxane / 26 h / |Reflux 2: lithium aluminium tetrahydride / tetrahydrofuran / 3 h / 0 °C / |Inert atmosphere 3: thionyl chloride / 2.25 h / 0 °C View Scheme
参考文献
Negoro, Kenji; Yonetoku, Yasuhiro; Misawa-Mukai, Hana; Hamaguchi, Wataru; Maruyama, Tatsuya; Yoshida, Shigeru; Takeuchi, Makoto; Ohta, Mitsuaki
Bioorganic and Medicinal Chemistry, 2012 , vol. 20, # 17 p. 5235 - 5246
反应条件
1: lithium aluminium tetrahydride / tetrahydrofuran / 3 h / 0 °C / |Inert atmosphere 2: thionyl chloride / 2.25 h / 0 °C View Scheme
参考文献
Negoro, Kenji; Yonetoku, Yasuhiro; Misawa-Mukai, Hana; Hamaguchi, Wataru; Maruyama, Tatsuya; Yoshida, Shigeru; Takeuchi, Makoto; Ohta, Mitsuaki
Bioorganic and Medicinal Chemistry, 2012 , vol. 20, # 17 p. 5235 - 5246
反应条件
1.1: lithium aluminium tetrahydride / diethyl ether; tetrahydrofuran / 20 °C 1.2: 1 h / 0 °C 2.1: thionyl chloride / dichloromethane / 2 h / 20 °C View Scheme
参考文献
MERCK SHARP and DOHME CORP.; KUDUK, Scott, D.; SCHLEGEL, Kelly-Ann; YANG, Zhi-Qiang
Patent: WO2011/84368 A1, 2011 ;
WO 2011/084368 A1
反应条件
1: 18-crown-6 ether / acetonitrile / 13 h / 20 °C
2: hydrogen; ammonium hydroxide / ethanol / 22 h / 20 °C
View Scheme
参考文献
Negoro, Kenji; Yonetoku, Yasuhiro; Misawa-Mukai, Hana; Hamaguchi, Wataru; Maruyama, Tatsuya; Yoshida, Shigeru; Takeuchi, Makoto; Ohta, Mitsuaki
Bioorganic and Medicinal Chemistry, 2012 , vol. 20, # 17 p. 5235 - 5246
