2-氨基-3,5-二溴吡啶合成路线 （共 36 条）
反应条件
1: With hydrogen bromide; bromine in water T=-5°C; 1 h; 2: With sodium nitrite in water T=-5 - 20°C;
参考文献
Burzicki, Gregory; Voisin-Chiret, Anne Sophie; Santos, Jana Sopkova-De Oliveira; Rault, Sylvain
Synthesis, 2010 , # 16 art. no. T06810SS, p. 2804 - 2810
反应条件
1,4-diaza-bicyclo[2.2.2]octane; palladium diacetate in N,N-dimethyl-formamide T=140°C; Heck reaction; 8 h; Inert atmosphere;
参考文献
Majumdar; Ganai, Sintu; Chattopadhyay, Buddhadeb; Ray, Krishanu
Synlett, 2011 , # 16 art. no. B10511ST, p. 2369 - 2373
反应条件
sulfuric acid; sodium nitrite Diazotization.Erwaermen der Diazoniumsalz-Loesung;
参考文献
Tschitschibabin; Tjashelowa
Zhurnal Russkago Fiziko-Khimicheskago Obshchestva, 1920 , vol. 50, p. 489
Chem. Zentralbl., 1923 , vol. 94, # III p. 1021
反应条件
hydrogenchloride; sodium nitrite
参考文献
Tschitschibabin; Woroshtzow
Chemische Berichte, 1933 , vol. 66, p. 364,368
反应条件
sulfuric acid; nitric acid
参考文献
Chemische Berichte, , vol. 61, p. 1230
Zhurnal Russkago Fiziko-Khimicheskago Obshchestva, , vol. 60, p. 975
参考文献
Chemische Berichte, , vol. 61, p. 1230
Zhurnal Russkago Fiziko-Khimicheskago Obshchestva, , vol. 60, p. 975
反应条件
1,4-diaza-bicyclo[2.2.2]octane; palladium diacetate in N,N-dimethyl-formamide
T=140°C; Heck reaction; 8 h; Inert atmosphere;
参考文献
Majumdar; Ganai, Sintu; Chattopadhyay, Buddhadeb; Ray, Krishanu
Synlett, 2011 , # 16 art. no. B10511ST, p. 2369 - 2373
反应条件
bis-triphenylphosphine-palladium(II) chloride; sodium carbonate in methanol; water; toluene
Suzuki coupling; 66 h; Heating;
参考文献
Yin, Lunxiang; Erdmann, Frank; Liebscher, Juergen
Journal of Heterocyclic Chemistry, 2005 , vol. 42, # 7 p. 1369 - 1379
反应条件
in methanol; water; toluene
参考文献
Takeda Pharmaceutical Company Limited
Patent: EP1845081 A1, 2007 ;
EP 1845081 A1
反应条件
bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triethylamine in N,N-dimethyl-formamide
T=110°C; Sonogashira coupling; 2 h;
参考文献
Majumdar; Mondal
Tetrahedron Letters, 2007 , vol. 48, # 39 p. 6951 - 6953
