1: 2,2,2-trifluoroethanol With sodium t-butanolate in DMF (N,N-dimethyl-formamide) T=0 - 25°C; 1 h; 2: 5-bromo-2-(2,2,2-trifluoroethoxy)benzoic acid With copper(I) bromide in DMF (N,N-dimethyl-formamide) T=100°C; 10 h;

potassium tert-butylate; copper monobromide in tetrahydrofuran; water

1: With pyridine; sodium hydroxide; copper(II) sulfate in water T=18 - 81°C; 1 h; 2: With NaMnO4 in water T=81 - 93°C; 7.75 h; 3: With hydrogenchloride in water pH=1 - 2; Product distribution / selectivity;

thionyl chloride T=80°C; 2 h;

1: 2,5-di-(2,2,2-trifluoroethoxy)benzoic acid With pivaloyl chloride; triethylamine in dichloromethane; N,N-dimethyl acetamide T=-30 - -20°C; 2: 2-Pyridinylmethylamine in dichloromethane; N,N-dimethyl acetamide T=-20°C; 2 h; 3: With sodium carbonate in dichloromethane; N,N-dimethyl acetamide; water Product distribution / selectivity;

in benzene