3-溴-4-甲氧基苯甲酸甲酯合成路线 （共 26 条）
反应条件
N-bromosuccinmide; CH3BF3(1-)*H(1+)*C4H10O in acetonitrile T=-10 - 20°C; 23 h; Inert atmosphere; regioselective reaction;
参考文献
Ogura, Tetsuhiro; Usuki, Toyonobu
Tetrahedron, 2013 , vol. 69, # 13 p. 2807 - 2815
反应条件
caesium carbonate in DMF (N,N-dimethyl-formamide) T=20°C; 21 h;
参考文献
ELI LILLY AND COMPANY
Patent: WO2005/100301 A1, 2005 ;
Location in patent: Page/Page column 55 ;
WO 2005/100301 A1
反应条件
caesium carbonate in N,N-dimethyl-formamide T=50°C; 16 h;
参考文献
WO2009/78983 A1, ;
Page/Page column 86 ;
WO 2009/078983 A1
反应条件
potassium carbonate in N,N-dimethyl-formamide T=25°C; 2 h;
参考文献
Patterson, John W.
Journal of Organic Chemistry, 1995 , vol. 60, # 14 p. 4542 - 4548
反应条件
sodium periodate; sulfuric acid; lithium bromide T=25°C; 18 h;
参考文献
Shaikh, Tanveer Mohammad Ali; Emmanuvel, Lourdusamy; Sudalai, Arumugam
Synthetic Communications, 2007 , vol. 37, # 16 p. 2641 - 2646
反应条件
Oxonereg;; sodium bromide in water T=20°C; 4 h;
参考文献
Synthetic Communications, , vol. 32, # 15 p. 2275 - 2286
反应条件
sodium hypochlorite; tetrabutylammomium bromide in ethyl acetate T=20°C; 2.5 h;
参考文献
Leduc, Andrew B.; Jamison, Timothy F.
Organic Process Research and Development, 2012 , vol. 16, # 5 p. 1082 - 1089
反应条件
Oxonereg;; sodium bromide in water T=20°C; 4 h;
参考文献
Synthetic Communications, , vol. 32, # 15 p. 2275 - 2286
反应条件
sulfuric acid Reflux;
参考文献
Kikuchi, Haruhisa; Matsuo, Yusuke; Katou, Yasuhiro; Kubohara, Yuzuru; Oshima, Yoshiteru
Tetrahedron, 2012 , vol. 68, # 43 p. 8884 - 8889
反应条件
tetrafluoroboric acid diethyl ether complex; N-bromosuccinmide in acetonitrile 23 h; Ambient temperature; Yield given. Yields of byproduct given;
参考文献
Journal of Organic Chemistry, , vol. 62, p. 4504 - 4506
