2-溴-5-甲氧基苯甲酸甲酯合成路线 （共 29 条）
反应条件
(i) Cu, 1-iodo-4-methoxy-benzene, (ii) aq. NaOH, MeOH; Multistep reaction;
参考文献
Horner,L.; Baston,D.W.
Justus Liebigs Annalen der Chemie, 1973 , p. 910 - 935
反应条件
1: sodium carbonate / tris(dibenzylideneacetone)dipalladium(0) / 1,2-dimethoxy-ethane; H2O / 16 h / 85 °C
2: sodium hydroxide / ethanol / 78 °C
View Scheme
参考文献
Epperson, James R.; Bruce, Marc A.; Catt, John D.; Deskus, Jeffrey A.; Hodges, Donald B.; Karageorge, George N.; Keavy, Daniel J.; Mahle, Cathy D.; Mattson, Ronald J.; Ortiz, Astrid A.; Parker, Michael F.; Takaki, Katherine S.; Watson, Brett T.; Yevich, Joseph P.
Bioorganic and Medicinal Chemistry, 2004 , vol. 12, # 17 p. 4601 - 4611
反应条件
1: 84 percent / sodium carbonate / tris(dibenzylideneacetone)dipalladium(0) / 1,2-dimethoxy-ethane; H2O / 16 h / 85 °C
2: 88 percent / sodium hydroxide / ethanol / 78 °C
View Scheme
参考文献
Epperson, James R.; Bruce, Marc A.; Catt, John D.; Deskus, Jeffrey A.; Hodges, Donald B.; Karageorge, George N.; Keavy, Daniel J.; Mahle, Cathy D.; Mattson, Ronald J.; Ortiz, Astrid A.; Parker, Michael F.; Takaki, Katherine S.; Watson, Brett T.; Yevich, Joseph P.
Bioorganic and Medicinal Chemistry, 2004 , vol. 12, # 17 p. 4601 - 4611
反应条件
(i) Cu, (ii) aq. NaOH, MeOH; Multistep reaction;
参考文献
Horner,L.; Baston,D.W.
Justus Liebigs Annalen der Chemie, 1973 , p. 910 - 935
反应条件
(i) Cu, (ii) aq. NaOH, MeOH; Multistep reaction;
参考文献
Horner,L.; Baston,D.W.
Justus Liebigs Annalen der Chemie, 1973 , p. 910 - 935
反应条件
1: (i) Cu, (ii) aq. NaOH, MeOH
2: polyphosphoric acid
3: aq. HBr / acetic acid
4: H2 / Pd-C / methanol
View Scheme
参考文献
Horner,L.; Baston,D.W.
Justus Liebigs Annalen der Chemie, 1973 , p. 910 - 935
反应条件
1.1: 57 percent / Pd(PPh3)4 / benzene / 20 h / 120 °C
2.1: 79 percent / NaOH / H2O; ethanol / 1 h / Heating
3.1: diethyl cyanophosphonate / dimethylformamide / 0.5 h / 0 °C
3.2: Et3N / dimethylformamide / 2 h / 0 °C
4.1: 63 percent / 1,4,8,11-tetraazacyclotetradecane based Ni(II) complex; tetraethylammonium tosylate / dimethylformamide / 60 °C / Electrolysis
View Scheme
参考文献
Ozaki, Shigeko; Adachi, Masashi; Sekiya, Sayaka; Kamikawa, Rie
Journal of Organic Chemistry, 2003 , vol. 68, # 11 p. 4586 - 4589
反应条件
1: PhMgCl / tetrahydrofuran / 1 h / -5 °C
2: 37.4 g / tetrahydrofuran / 5 h / -10 - 25 °C
View Scheme
参考文献
Reynolds, Dominic J; Hermitage, Stephen A
Tetrahedron, 2001 , vol. 57, # 36 p. 7765 - 7770
反应条件
1: 57 percent / Pd(PPh3)4 / benzene / 20 h / 120 °C
2: 79 percent / NaOH / H2O; ethanol / 1 h / Heating
View Scheme
参考文献
Ozaki, Shigeko; Adachi, Masashi; Sekiya, Sayaka; Kamikawa, Rie
Journal of Organic Chemistry, 2003 , vol. 68, # 11 p. 4586 - 4589
