胸腺嘧啶脱氧核苷-5-羧酸合成路线 （共 11 条）
反应条件
oxygen; sodium hydrogencarbonate; platinum on activated charcoal in water T=70°C;
参考文献
Jung, Michael E.; Xu, Yue
Heterocycles, 1998 , vol. 47, # 1 p. 349 - 356
反应条件
dipotassium peroxodisulfate; RuCl3; potassium hydroxide in water T=20°C; 3.5 h;
参考文献
Debnath, Joy; Dasgupta, Swagata; Pathak, Tanmaya
Bioorganic and Medicinal Chemistry, 2010 , vol. 18, # 23 p. 8257 - 8263
反应条件
air; thiophenol in tetrahydrofuran T=85°C; 1 h;
参考文献
Montevecchi, Pier Carlo; Manetto, Antonio; Navacchia, Maria Luisa; Chatgilialoglu, Chryssostomos
Tetrahedron, 2004 , vol. 60, # 19 p. 4303 - 4308
反应条件
air T=85°C; 1 h; Title compound not separated from byproducts.;
参考文献
Montevecchi, Pier Carlo; Manetto, Antonio; Navacchia, Maria Luisa; Chatgilialoglu, Chryssostomos
Tetrahedron, 2004 , vol. 60, # 19 p. 4303 - 4308
反应条件
air; thiophenol T=85°C; 1 h;
参考文献
Montevecchi, Pier Carlo; Manetto, Antonio; Navacchia, Maria Luisa; Chatgilialoglu, Chryssostomos
Tetrahedron, 2004 , vol. 60, # 19 p. 4303 - 4308
反应条件
borane in tetrahydrofuran 20 h; Ambient temperature;
参考文献
Frank; Worth Jr.; Christner; Kozarich; Stubbe; Kappen; Goldberg
Journal of the American Chemical Society, 1991 , vol. 113, # 6 p. 2271 - 2275
反应条件
1: 77 percent / triethylamine, diphenylphosphoryl azide / dimethylformamide / 1.) -20 deg C, 1 h, 2.) 20 deg C, 20 h
2: 41 percent / NaNO2, formic acid / 0.5 h
View Scheme
参考文献
Montgomery, John A.; Thomas, H. Jeanette; Brockman, R. Wallace; Wheeler, Glynn P.
Journal of Medicinal Chemistry, 1981 , vol. 24, # 2 p. 184 - 189
反应条件
1: 84 percent / triethylamine, diphenylphosphoryl azide / dimethylformamide / 1.) -20 deg C, 1 h, 2.) 20 deg C, 20 h
2: 58 percent / NaNO2, formic acid / 0.5 h
View Scheme
参考文献
Montgomery, John A.; Thomas, H. Jeanette; Brockman, R. Wallace; Wheeler, Glynn P.
Journal of Medicinal Chemistry, 1981 , vol. 24, # 2 p. 184 - 189
反应条件
diphenylphosphoranyl azide; triethylamine in N,N-dimethyl-formamide
1.) -20 deg C, 1 h, 2.) 20 deg C, 20 h;
参考文献
Montgomery, John A.; Thomas, H. Jeanette; Brockman, R. Wallace; Wheeler, Glynn P.
Journal of Medicinal Chemistry, 1981 , vol. 24, # 2 p. 184 - 189
反应条件
diphenylphosphoranyl azide; triethylamine in N,N-dimethyl-formamide
1.) -20 deg C, 1 h, 2.) 20 deg C, 20 h;
参考文献
Montgomery, John A.; Thomas, H. Jeanette; Brockman, R. Wallace; Wheeler, Glynn P.
Journal of Medicinal Chemistry, 1981 , vol. 24, # 2 p. 184 - 189
