3-(3-氨基苯基)丙酸甲酯合成路线 （共 6 条）
反应条件
thionyl chloride T=0 - 20°C; 3 h;
参考文献
PHARMAGENE LABORATORIES LIMITED
Patent: WO2005/80367 A1, 2005 ;
Location in patent: Page/Page column 64; 116-117 ;
反应条件
hydrogen; palladium on activated charcoal in methanol; benzene T=25°C; 24 h;
参考文献
Suzuki, Masaaki; Koyano, Hiroshi; Noyori, Ryoji; Hashimoto, Hitoshi; Negishi, Manabu; Ichikawa, Atsushi; Ito, Seiji
Tetrahedron, 1992 , vol. 48, # 13 p. 2635 - 2658
参考文献
Flynn, Daniel L.; Petillo, Peter A.
Patent: US2005/288286 A1, 2005 ;
Title/Abstract Full Text Show Details
Deciphera Pharmaceuticals, LLC
Patent: US7666895 B2, 2010 ;
反应条件
hydrogen; palladium on activated charcoal
参考文献
Hashizume; Ito; Morikawa; Kanaya; Nagashima; Usui; Tomoda; Sunazuka; Kumagai; Omura
Chemical and Pharmaceutical Bulletin, 1994 , vol. 42, # 10 p. 2097 - 2107
反应条件
1: H2SO4 2: 95 percent / H2 / 5percent Pd/C / methanol; benzene / 24 h / 25 °C View Scheme
参考文献
Suzuki, Masaaki; Koyano, Hiroshi; Noyori, Ryoji; Hashimoto, Hitoshi; Negishi, Manabu; Ichikawa, Atsushi; Ito, Seiji
Tetrahedron, 1992 , vol. 48, # 13 p. 2635 - 2658
反应条件
1: 1.) NaOMe / 1.) methanol, 10 min, 2.) methanol, RT, 1 h 2: H2 / 5percent Pd/C / methanol / 3 h / Ambient temperature View Scheme
参考文献
Hashizume; Ito; Morikawa; Kanaya; Nagashima; Usui; Tomoda; Sunazuka; Kumagai; Omura
Chemical and Pharmaceutical Bulletin, 1994 , vol. 42, # 10 p. 2097 - 2107
