反应条件
1: 90 percent / tetrahydrofuran / 12 h / 65 °C
2: 91 percent / LiAlH4 / diethyl ether / 5 h / 25 °C
3: 76 percent / dimethyl(S,S)(-)-tartarate
4: 90 percent / H2 / Lindlar / tetrahydrofuran / 760 Torr
5: 84 percent / O2 / oxidation with Collins reagent
6: 94 percent / tetrahydrofuran / -78 deg C, 10 min,; and then from -78 deg Cto 0 deg C over 1 h.
7: 84 percent / acetic acid; acetonitrile; H2O / 6 h / 25 °C
8: triphenylphosphine, imidazole, I2, diisopropylamine / diethyl ether; acetonitrile / 0.67 h / 25 °C
9: acetonitrile / 16 h / 60 °C
11: 1.) potassium isopropoxide; 2.) base / 1.) 0 deg C, 1 h; 2.) hydrolysis
View Scheme
参考文献
Corey, E. J.; Pyne, Stephen G.; Su, Wei-Gou
Tetrahedron Letters, 1983 , vol. 24, # 45 p. 4883 - 4886
