1-氧杂环十五烷-2-酮合成路线 （共 40 条）
反应条件
1: 1.) t-butyllithium, 2.) NH4Cl/NH4OH / 1.) THF, from -78 deg C to 25 deg C and 15 min at room temperature, 2.) 40 deg C, H2O 2: BF3 etherate / diethyl ether 3: 30 percent / aq. 3N HCl View Scheme
参考文献
Genet, Jean Pierre; Kahn, Philippe
Tetrahedron Letters, 1980 , vol. 21, p. 1521 - 1524
反应条件
1: 90 percent / MCPBA / CH2Cl2 / 20 h / Heating 2: 97 percent / HCl / 3 h / 25 °C 3: 85 percent / diisopropylethylamine / 18 h / 150 °C / other reaction conditions 4: 1.) LiAlH4, 2.) H2O / 1.)Et2O, 2 h 5: methyltriphenoxyphosphonium iodide 6: 2.) NH4Cl/NH4OH / 1.) HMPA, THF, 70 deg C, 3 h, 2.) -40 deg C 7: 1.) t-butyllithium, 2.) NH4Cl/NH4OH / 1.) THF, from -78 deg C to 25 deg C and 15 min at room temperature, 2.) 40 deg C, H2O 8: BF3 etherate / diethyl ether 9: 30 percent / aq. 3N HCl View Scheme
参考文献
Genet, Jean Pierre; Kahn, Philippe
Tetrahedron Letters, 1980 , vol. 21, p. 1521 - 1524
反应条件
in tetrachloromethane 6 h; Heating;
参考文献
Torra, Nuria; Urpi, Felix; Vilarrasa, Jaume
Tetrahedron, 1989 , vol. 45, # 3 p. 863 - 868
反应条件
1: 87 percent / silver perchlorate / 72 h / Ambient temperature 2: 85 percent / K2CO3 / acetone / 12 h / Heating View Scheme
参考文献
Matsuyama, Haruo; Nakamura, Takako; Kamigata, Nobumasa
Journal of Organic Chemistry, 1989 , vol. 54, # 22 p. 5218 - 5223
反应条件
1: 90 percent / pyridine, N2O4 / 1 h / -10 °C 2: 80 percent / CCl4 / 6 h / Heating View Scheme
参考文献
Torra, Nuria; Urpi, Felix; Vilarrasa, Jaume
Tetrahedron, 1989 , vol. 45, # 3 p. 863 - 868
反应条件
1: 1.) LDA / 1.) THF, -78 deg C, 1.5h, 2.) -78 deg C, 10 min 2: 2N HCl / tetrahydrofuran / 3 h / 60 °C 3: 1.) oxygen, Sensitox (Rose Bengal polymer), 2.) p-toluenesulfonic acid / 1.) irradiation in CH2Cl2, 30 min, 2.) heating in benzene, 24 h View Scheme
参考文献
Wasserman, Harry H.; Gambale, Ronald J.; Pulwer, Mitchell J.
Tetrahedron Letters, 1981 , vol. 22, # 18 p. 1737 - 1740
参考文献
Genet, Jean Pierre; Kahn, Philippe
Tetrahedron Letters, 1980 , vol. 21, p. 1521 - 1524
反应条件
1: p-TolSO3H / benzene / Heating 2: 86 percent / NaBH3CN / methanol / 3 h / Ambient temperature; Irradiation View Scheme
参考文献
Abe, Motoji; Hayashikoshi, Takaoki; Kurata, Takeo
Chemistry Letters, 1994 , # 10 p. 1789 - 1792
反应条件
in benzene T=40°C; 72 h; Lipase P;
参考文献
Makita, Atushi; Nihira, Takuya; Yamada, Yasuhiro
Tetrahedron Letters, 1987 , vol. 28, # 7 p. 805 - 808
反应条件
Sensitox (Rose Bengal polymer); oxygen; toluene-4-sulfonic acid 1.) irradiation in CH2Cl2, 30 min, 2.) heating in benzene, 24 h; Yield given. Multistep reaction;
参考文献
Wasserman, Harry H.; Gambale, Ronald J.; Pulwer, Mitchell J.
Tetrahedron Letters, 1981 , vol. 22, # 18 p. 1737 - 1740
