5-硝基吡啶-2,3-二胺合成路线 （共 13 条）
反应条件
(NH4)2S in methanol; water T=75°C;
参考文献
Newhouse, Bradley J.; Wenglowsky, Steve; Grina, Jonas; Laird, Ellen R.; Voegtli, Walter C.; Ren, Li; Ahrendt, Kateri; Buckmelter, Alex; Gloor, Susan L.; Klopfenstein, Nathalie; Rudolph, Joachim; Wen, Zhaoyang; Li, Xianfeng; Feng, Bainian
Bioorganic and Medicinal Chemistry Letters, 2013 , vol. 23, # 21 p. 5896 - 5899
反应条件
1: 89 percent / aq. NH4OH / ethanol / 0.25 h / Ambient temperature 2: 80 percent / aq.(NH4)2S / methanol / 0.5 h / Heating View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 40, # 22 p. 3679 - 3686
反应条件
1: 70 percent / POCl3 / 1.) RT, 0.5 h, 2.) reflux, 6 h 2: m-chloroperbenzoic acid / CHCl3 / 1.5 h / -15 °C 3: 43 percent / H2 / 10percent Pd/C / ethanol / 760 Torr View Scheme
参考文献
Barraclough; Black; Cambridge; Collard; Firmin; Gerskowitch; Glen; Giles; Hill; Hull; Iyer; King; Kneen; Lindon; Nobbs; Randall; Shah; Smith; Vine; et al.
Journal of Medicinal Chemistry, 1990 , vol. 33, # 8 p. 2231 - 2239
反应条件
1: trichlorophosphate / |Reflux 2: ammonium chloride; zinc / water; ethanol View Scheme
参考文献
Newhouse, Bradley J.; Wenglowsky, Steve; Grina, Jonas; Laird, Ellen R.; Voegtli, Walter C.; Ren, Li; Ahrendt, Kateri; Buckmelter, Alex; Gloor, Susan L.; Klopfenstein, Nathalie; Rudolph, Joachim; Wen, Zhaoyang; Li, Xianfeng; Feng, Bainian
Bioorganic and Medicinal Chemistry Letters, 2013 , vol. 23, # 21 p. 5896 - 5899
反应条件
1: T=100°C; 6 h; 2: With sodium hydroxide in water pH=7;
参考文献
ARRAY BIOPHARMA INC.; GENENTECH, INC.
Patent: WO2009/111277 A1, 2009 ;
Location in patent: Page/Page column 53 ;
WO 2009/111277 A1
反应条件
hydrogenchloride Heating;
参考文献
Ohmori; Kubota; Shimizu-Sasamata; Okada; Sakamoto
Journal of Medicinal Chemistry, 1996 , vol. 39, # 6 p. 1331 - 1338
参考文献
State of Oregon, acting by and through The Oregon State Board of Higher Education, acting for and on behalf of The Oregon Health Sciences University and The University of Oregon, Eugene Oregon; The Regents of the University of California; ACEA Pharmaceuticals, Inc.
Patent: US5620978 A1, 1997 ;
US 5620978 A
反应条件
1: trichlorophosphate / |Reflux 2: ammonium chloride; zinc / water; ethanol View Scheme
参考文献
Newhouse, Bradley J.; Wenglowsky, Steve; Grina, Jonas; Laird, Ellen R.; Voegtli, Walter C.; Ren, Li; Ahrendt, Kateri; Buckmelter, Alex; Gloor, Susan L.; Klopfenstein, Nathalie; Rudolph, Joachim; Wen, Zhaoyang; Li, Xianfeng; Feng, Bainian
Bioorganic and Medicinal Chemistry Letters, 2013 , vol. 23, # 21 p. 5896 - 5899
反应条件
T=175°C; 1.25 h; Irradiation with microwave;
参考文献
ARRAY BIOPHARMA INC.; GENENTECH, INC.
Patent: WO2009/111277 A1, 2009 ;
Location in patent: Page/Page column 57 ;
WO 2009/111277 A1
