6-硝基-3H-咪唑并[4,5-b]吡啶合成路线 (共 3 条)
反应条件
1: T=100°C; 6 h; 2: With sodium hydroxide in water pH=7;
参考文献
ARRAY BIOPHARMA INC.; GENENTECH, INC.
Patent: WO2009/111277 A1, 2009 ;
Location in patent: Page/Page column 53 ;
WO 2009/111277 A1
反应条件
1: (NH4)2S / water; methanol / |Reflux 2: trichlorophosphate / |Reflux View Scheme
参考文献
Newhouse, Bradley J.; Wenglowsky, Steve; Grina, Jonas; Laird, Ellen R.; Voegtli, Walter C.; Ren, Li; Ahrendt, Kateri; Buckmelter, Alex; Gloor, Susan L.; Klopfenstein, Nathalie; Rudolph, Joachim; Wen, Zhaoyang; Li, Xianfeng; Feng, Bainian
Bioorganic and Medicinal Chemistry Letters, 2013 , vol. 23, # 21 p. 5896 - 5899
反应条件
hydrogen; palladium 10 on activated carbon in ethanol T=20°C;
参考文献
Newhouse, Bradley J.; Wenglowsky, Steve; Grina, Jonas; Laird, Ellen R.; Voegtli, Walter C.; Ren, Li; Ahrendt, Kateri; Buckmelter, Alex; Gloor, Susan L.; Klopfenstein, Nathalie; Rudolph, Joachim; Wen, Zhaoyang; Li, Xianfeng; Feng, Bainian
Bioorganic and Medicinal Chemistry Letters, 2013 , vol. 23, # 21 p. 5896 - 5899