4-异丙氧基-3-甲氧基苯甲酸合成路线 （共 4 条）
反应条件
1: 4-bromo-1-isopropoxy-2-methoxy-benzene With tert.-butyl lithium in tetrahydrofuran; toluene T=-78°C; 1 h; Inert atmosphere; 2: carbon dioxide in tetrahydrofuran T=-78 - 20°C; 0.5 h; Inert atmosphere;
参考文献
VERTEX PHARMACEUTICALS INCORPORATED; LITTLER, Benjamin, Joseph; KESHAVARZ-SHOKRI, Ali; ZHANG, Beili; HUGHES, Robert, Michael
Patent: WO2014/22639 A1, 2014 ;
Location in patent: Paragraph 00188-00190 ;
反应条件
potassium permanganate
参考文献
Journal of the American Chemical Society, , vol. 77, p. 757
反应条件
1.1: potassium carbonate / N,N-dimethyl-formamide / 0.25 h / 20 °C / Inert atmosphere 1.2: 4 h / Inert atmosphere; Reflux 2.1: potassium hydroxide / ethanol; water / 4 h / Reflux 2.2: pH 3 View Scheme
参考文献
Bioorganic and Medicinal Chemistry, , vol. 19, # 16 p. 4971 - 4984
反应条件
1.1: potassium carbonate / dimethyl sulfoxide / 2 h / 20 - 55 °C 2.1: tert.-butyl lithium / tetrahydrofuran; toluene / 1 h / -78 °C / |Inert atmosphere 2.2: 0.5 h / -78 - 20 °C / |Inert atmosphere View Scheme
