5-氨基-3-甲基-4-异恶唑甲酰胺合成路线 （共 10 条）
反应条件
sulfuric acid; nitric acid T=9°C; 48 h;
参考文献
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), , p. 1509 - 1512
反应条件
sodium tetrahydroborate; acetic acid in tetrahydrofuran 0.5 h; Heating;
参考文献
Ryng; Machon; Wieczorek; Zimecki; Mokrosz
European Journal of Medicinal Chemistry, 1998 , vol. 33, # 10 p. 831 - 836
反应条件
1: NH2OH*HCl, aq. NaOH 2: (i) H2SO4, (ii) aq. NH3 View Scheme
参考文献
Journal of Organic Chemistry, , vol. 29, p. 2116 - 2120
反应条件
(i) H2SO4, (ii) aq. NH3; Multistep reaction;
参考文献
Journal of Organic Chemistry, , vol. 29, p. 2116 - 2120
反应条件
sodium ethanolate in ethanol 7 h; Heating;
参考文献
Miyashita, Akira; Fujimoto, Katsuhiro; Okada, Tomomi; Higashino, Takeo
Heterocycles, 1996 , vol. 42, # 2 p. 691 - 699
反应条件
acetic anhydride T=120°C;
参考文献
Alyabiev, Sergey B.; Kravchenko, Dmitri V.; Ivachtchenko, Alexandre V.
Mendeleev Communications, 2008 , vol. 18, # 3 p. 144 - 146
反应条件
sodium ethanolate in ethanol
7 h; Heating;
参考文献
Miyashita, Akira; Fujimoto, Katsuhiro; Okada, Tomomi; Higashino, Takeo
Heterocycles, 1996 , vol. 42, # 2 p. 691 - 699
反应条件
T=190°C; 4 h; Neat (no solvent)Inert atmosphere;
参考文献
Ho, Jonathan Z.; Van Arsdale, Kyle R.; Braun, Matthew P.
Helvetica Chimica Acta, 2008 , vol. 91, # 5 p. 958 - 963
反应条件
acetic anhydride
3 h; Heating;
参考文献
Alyabiev, Sergey B.; Kravchenko, Dmitri V.; Ivachtchenko, Alexandre V.
Mendeleev Communications, 2008 , vol. 18, # 3 p. 144 - 146
反应条件
1: in acetic anhydride
T=20 - 160°C; 3 h; Heating / reflux;
2: With ammonia in water
3: With acetic acid in water
参考文献
CYTOVIA, INC.
Patent: WO2008/57402 A2, 2008 ;
Location in patent: Page/Page column 50 ;
WO 2008/057402 A2
