5-氨基-3-甲基-4-异恶唑甲腈合成路线 (共 9 条)
反应条件
sodium hydroxide; hydroxylamine hydrochloride in ethanol; water T=20 - 50°C;
参考文献
TIBOTEC PHARMACEUTICALS LTD.
Patent: WO2006/35061 A1, 2006 ;
Location in patent: Page/Page column 29 ;
反应条件
iodine; sodium hydrogencarbonate in tetrahydrofuran; water 0.5 h;
参考文献
Journal of Heterocyclic Chemistry, , vol. 27, # 5 p. 1481 - 1484
反应条件
1: 72 percent / tetramethylguanidine, hydroxylamine hydrochloride / CHCl3 / 2 h 2: 15 percent / hydrogen peroxide / pyridine / 24 h / 0 °C View Scheme
参考文献
Journal of Heterocyclic Chemistry, , vol. 27, # 5 p. 1481 - 1484
反应条件
sulfuric acid; nitric acid T=9°C; 48 h;
参考文献
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), , p. 1509 - 1512
反应条件
(i) H2SO4, (ii) aq. NH3; Multistep reaction;
参考文献
Taylor,E.C.; Garcia,E.E.
Journal of Organic Chemistry, 1964 , vol. 29, p. 2116 - 2120
反应条件
N-ethyl-N,N-diisopropylamine in tetrahydrofuran; acetonitrile
T=20°C;
参考文献
TIBOTEC PHARMACEUTICALS LTD.
Patent: WO2006/35061 A1, 2006 ;
Location in patent: Page/Page column 29; 30 ;
反应条件
1: (i) H2SO4, (ii) aq. NH3
2: Ac2O / 3 h / Heating
View Scheme
参考文献
Taylor,E.C.; Garcia,E.E.
Journal of Organic Chemistry, 1964 , vol. 29, p. 2116 - 2120
反应条件
acetic anhydride
4 h; Heating;
参考文献
Taylor,E.C.; Garcia,E.E.
Journal of Organic Chemistry, 1964 , vol. 29, p. 2116 - 2120
反应条件
(i) Ac2O, (ii) NH3, EtOH; Multistep reaction;
参考文献
Taylor,E.C.; Garcia,E.E.
Journal of Organic Chemistry, 1964 , vol. 29, p. 2116 - 2120