2-溴-4，5-二甲氧基苯丙腈合成路线 （共 14 条）
反应条件
N-bromosuccinmide in N,N-dimethyl-formamide T=0 - 20°C; 2.5 h;
参考文献
LES LABORATOIRES SERVIER; CARRANZA, Maria Del Pilar; GARCIA ARANDA, Maria Isabel; GONZALEZ, José Lorenzo; SANCHEZ, Frédéric
Patent: US2014/107334 A1, 2014 ;
Location in patent: Paragraph 0044-0047 ;
反应条件
sodium acetate in acetic acid
参考文献
US2014/128598 A1, ;
Page/Page column ;
反应条件
pyridine; sodium tetrahydroborate in methanol 2 h; Reflux;
参考文献
Zhao, Sheng Yin; Liang, Hong Yu; Shao, Zhi Yu; Chen, Rui
Journal of Chemical Research, 2009 , # 7 p. 420 - 422
反应条件
in isobutyramide T=170°C; 2 h;
参考文献
Zhao, Sheng Yin; Liang, Hong Yu; Shao, Zhi Yu; Chen, Rui
Journal of Chemical Research, 2009 , # 7 p. 420 - 422
反应条件
1: potassium tert-butylate / tetrahydrofuran / 0 - 20 °C 2: sodium tetrahydroborate; methanol; pyridine / 9 h / 100 °C 3: N-bromosuccinmide / N,N-dimethyl-formamide / 2.5 h / 0 - 20 °C View Scheme
反应条件
1: sodium tetrahydroborate; hydrogenchloride / pyridine; methanol 2: sodium acetate / acetic acid View Scheme
反应条件
1: sodium acetate; tetrabutylammomium bromide / ethyl acetate 2: sodium tetrahydroborate; hydrogenchloride / pyridine; methanol 3: sodium acetate / acetic acid View Scheme
反应条件
n-butyllithium in tetrahydrofuran; hexane T=-10°C; Inert atmosphere;
参考文献
RICHTER GEDEON NYRT.; UJVARI, Viktor; BODI, Jozsef; FARAGO, Janos; SZKE, Katalin; FAIGL, Ferenc; NEMET, Zoltan; TEMESVARI, Krisztina; KISS, Robert; MATRAVOeLGYI, Bela; KASSAI, Ferencne; KISS-BARTOS, Dorottya
Patent: WO2011/138625 A1, 2011 ;
Location in patent: Page/Page column 31-32 ;
反应条件
1.1: n-butyllithium / hexane; tetrahydrofuran / -10 °C / Inert atmosphere 2.1: potassium hydroxide; water / 4 h / Reflux 2.2: 20 °C 3.1: ethyl acetate / 1.25 h / 0 °C / Reflux 4.1: hydrogenchloride / dichloromethane; water / 0.08 h 5.1: oxalyl dichloride / N,N-dimethyl-formamide / dichloromethane / 15 - 25 °C 6.1: dichloromethane; water / 0 - 10 °C 7.1: borane-THF / tetrahydrofuran / 20 - 50 °C 7.2: 0.25 h / 0 - 5 °C 7.3: 2.5 h / 0 °C / Reflux View Scheme
参考文献
RICHTER GEDEON NYRT.; UJVARI, Viktor; BODI, Jozsef; FARAGO, Janos; SZKE, Katalin; FAIGL, Ferenc; NEMET, Zoltan; TEMESVARI, Krisztina; KISS, Robert; MATRAVOeLGYI, Bela; KASSAI, Ferencne; KISS-BARTOS, Dorottya
Patent: WO2011/138625 A1, 2011 ;
反应条件
1: ammonia; sodium; anhydrous iron chloride / 2 h / 20 °C 2: borane-THF / ethanol; tetrahydrofuran / 13 h View Scheme
参考文献
LES LABORATOIRES SERVIER; CARRANZA, Maria Del Pilar; GARCIA ARANDA, Maria Isabel; GONZALEZ, José Lorenzo; SANCHEZ, Frédéric
Patent: US2014/163220 A1, 2014 ;
