(+/-)-2-氨基十二酸合成路线 （共 10 条）
反应条件
ammonium hydroxide 168 h; Ambient temperature;
参考文献
Khare; Becker; Naider
Journal of Medicinal Chemistry, 1988 , vol. 31, # 3 p. 650 - 656
反应条件
potassium hydroxide in methanol 2 h; Ambient temperature;
参考文献
Landini, Dario; Penso, Michele
Journal of Organic Chemistry, 1991 , vol. 56, # 1 p. 420 - 423
反应条件
1: 75 percent / K2CO3 / benzyltriethylammonium chloride / acetonitrile / 3.5 h / Heating 2: 100 percent / 20percent aq. KOH / methanol / 2 h / Ambient temperature View Scheme
参考文献
Journal of Organic Chemistry, , vol. 56, # 1 p. 420 - 423
反应条件
hydrogenchloride in N,N-dimethyl-formamide Heating; Yield given;
参考文献
Liebigs Annalen der Chemie, , # 12 p. 1175 - 1183
反应条件
potassium hydroxide; N-benzyl-N,N,N-triethylammonium chloride in diethyl ether T=35°C; 168 h; Yield given. Yields of byproduct given;
参考文献
Journal of the Chemical Society - Perkin Transactions 1, , # 3 p. 247 - 249
反应条件
1: Na; EtOH / Heating 2: conc. HCl / Heating View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 12, # 18 p. 2635 - 2637
反应条件
1: With sodium ethanolate Heating; 2: With hydrogenchloride Heating;
参考文献
Bioorganic and Medicinal Chemistry, , vol. 14, # 14 p. 4775 - 4780
反应条件
1: Br2, PCl3 2: NH3 View Scheme
参考文献
Bulletin of the Chemical Society of Japan, , vol. 71, # 4 p. 789 - 796
反应条件
1: 63 percent / 2N aq. NaOH 3: 99 percent / 3N aq. HCl / 4.5 h / Heating View Scheme
参考文献
Endo, Yasuyuki; Ohno, Michihiro; Takehana, Shunji; Driedger, Paul E.; Stabel, Silvia; Shudo, Koichi
Chemical and Pharmaceutical Bulletin, 1997 , vol. 45, # 2 p. 424 - 426
反应条件
1: 63 percent / 2N aq. NaOH 2: 49 percent / 3N HCl, Aspergillus aminoacylase, CoCl2 / H2O / 19 h / 37 °C View Scheme
参考文献
Endo, Yasuyuki; Takehana, Shunji; Ohno, Michihiro; Driedger, Paul E.; Stabel, Silvia; Mizutani, Miho Y.; Tomioka, Nobuo; Itai, Akiko; Shudo, Koichi
Journal of Medicinal Chemistry, 1998 , vol. 41, # 9 p. 1476 - 1496
