2-氨基-2-(2-氯苯基)环己酮盐酸盐合成路线 （共 9 条）
反应条件
in isopropyl alcohol 120 h; Reflux;
参考文献
Li, Yibai; Coller, Janet K.; Hutchinson, Mark R.; Klein, Kathrin; Zanger, Ulrich M.; Stanley, Nathan J.; Abell, Andrew D.; Somogyi, Andrew A.
Drug Metabolism and Disposition, 2013 , vol. 41, # 6 p. 1264 - 1272
反应条件
in various solvent(s) T=180°C; 0.116667 h;
参考文献
Parcell, Robert F.; Sanchez, Joseph P.
Journal of Organic Chemistry, 1981 , vol. 46, # 25 p. 5055 - 5060
反应条件
1: 60 percent / 28percent ammonium hydroxide saturated with anhydrous ammonia / 168 h / Ambient temperature 2: 16 g / propan-2-ol / 120 h / Heating View Scheme
参考文献
Parcell, Robert F.; Sanchez, Joseph P.
Journal of Organic Chemistry, 1981 , vol. 46, # 25 p. 5055 - 5060
反应条件
1: N-bromosuccinmide; toluene-4-sulfonic acid / dichloromethane / 6 h 2: ammonia / 18 h / -78 °C 3: isopropyl alcohol / 120 h / |Reflux View Scheme
参考文献
Jose, Jiney; Gamage, Swarna A.; Harvey, Martyn G.; Voss, Logan J.; Sleigh, James W.; Denny, William A.
Bioorganic and Medicinal Chemistry, 2013 , vol. 21, # 17 p. 5098 - 5106
反应条件
1.1: magnesium; iodine / diethyl ether / 1 h 1.2: 16 h 2.1: N-bromosuccinmide; toluene-4-sulfonic acid / dichloromethane / 6 h 3.1: ammonia / 18 h / -78 °C 4.1: isopropyl alcohol / 120 h / |Reflux View Scheme
参考文献
Li, Yibai; Coller, Janet K.; Hutchinson, Mark R.; Klein, Kathrin; Zanger, Ulrich M.; Stanley, Nathan J.; Abell, Andrew D.; Somogyi, Andrew A.
Drug Metabolism and Disposition, 2013 , vol. 41, # 6 p. 1264 - 1272
反应条件
in vivo metabolism in rats;
参考文献
Lai; Hong; Davisson
Journal of Pharmaceutical Sciences, 1985 , vol. 74, # 4 p. 486 - 488
反应条件
sodium hydroxide; hydrogen bromide; bromine
1.) glacial acetic acid, 35 deg C, 1.5 h, 2.) 0 deg C; Yield given. Multistep reaction. Yields of byproduct given;
参考文献
Lai; Hong; Davisson
Journal of Pharmaceutical Sciences, 1985 , vol. 74, # 4 p. 486 - 488
反应条件
in vivo metabolism in rats;
参考文献
Lai; Hong; Davisson
Journal of Pharmaceutical Sciences, 1985 , vol. 74, # 4 p. 486 - 488
反应条件
in vivo metabolism in rats;
参考文献
Lai; Hong; Davisson
Journal of Pharmaceutical Sciences, 1985 , vol. 74, # 4 p. 486 - 488
