(5-甲基异恶唑-3-基)甲醇合成路线 （共 17 条）
反应条件
1: With lithium aluminium tetrahydride in tetrahydrofuran T=-75 - 20°C; 2: With hydrogenchloride in water pH=1 - 2;
参考文献
Hogenkamp, Derk J.; Johnstone, Timothy B.C.; Gee, Kelvin W.
Patent: US2006/293329 A1, 2006 ;
Location in patent: Page/Page column 19 ;
反应条件
sodium tetrahydroborate in ethanol
参考文献
Masciadri, Raffaello; Thomas, Andrew William; Wichmann, Juergen
Patent: US2003/55042 A1, 2003 ;
反应条件
1: With lithium aluminium tetrahydride in tetrahydrofuran T=0 - 26°C; 2: With acetic acid in tetrahydrofuran
参考文献
WO2011/132048 A1, ;
Page/Page column 40 ;
WO 2011/132048 A1
参考文献
Beecham Group p.l.c.
Patent: US4812470 A1, 1989 ;
反应条件
1: 74 percent / NH2OH*HCl / ethanol / 2 h / Heating 2: 60 percent / LiAlH4 / tetrahydrofuran / 0.5 h / -78 °C View Scheme
参考文献
Tetrahedron Letters, , vol. 34, # 47 p. 7509 - 7512
反应条件
hydroxylamine hydrochloride; sodium acetate in ethanol 24 h; Heating; Yield given. Yields of byproduct given. Title compound not separated from byproducts;
参考文献
Synthesis, , # 10 p. 868 - 870
反应条件
n-butyllithium 1.) THF, -78 deg C, 15 min, 2.) RT; Yield given. Multistep reaction;
参考文献
Sterling Drug Inc.
Patent: US5110821 A1, 1992 ;
反应条件
thionyl chloride in dichloromethane T=20°C; 1.33333 h; Heating / reflux;
参考文献
Hogenkamp, Derk J.; Johnstone, Timothy B.C.; Gee, Kelvin W.
Patent: US2006/293329 A1, 2006 ;
Location in patent: Page/Page column 19 ;
反应条件
potassium dichromate; sulfuric acid
参考文献
Speroni; Pino
Atti della Accademia Nazionale dei Lincei, Classe di Scienze Fisiche, Matematiche e Naturali, Rendiconti, 1952 , vol. <8> 13, p. 39,40
反应条件
potassium dichromate; sulfuric acid
参考文献
Quilico; Panizzi
Gazzetta Chimica Italiana, 1939 , vol. 69, p. 536,541
