1-(3,5-二甲基-4-异噁唑基)-乙酮合成路线 （共 12 条）
反应条件
pyridinium chlorochromate in dichloromethane T=0 - 20°C; 1 h;
参考文献
TEMPERO PHARMACEUTICALS, INC.; BALOGLU, Erkan; BOHNERT, Gary, J.; GHOSH, Shomir; LOBERA, Mercedes; SCHMIDT, Darby, R.; SUNG, Leonard
Patent: WO2013/19682 A1, 2013 ;
Location in patent: Page/Page column 93 ;
WO 2013/019682 A1
反应条件
1: in tetrahydrofuran T=0 - 20°C; 4 h; 2: With hydrogenchloride in tetrahydrofuran; water T=20°C; 1 h;
参考文献
SANOFI; EL-AHMAD, Youssef; FILOCHE-ROMME, Bruno; GANZHORM, Axel; MARCINIAK, Gilbert; MUZET, Nicolas; RONAN, Baptiste; VIVET, Bertrand; ZERR, Véronique
Patent: WO2013/190123 A1, 2013 ;
Location in patent: Page/Page column 48; 49 ;
反应条件
sodium ethanolate in ethanol Heating;
参考文献
Padwa,A. et al.
Journal of the American Chemical Society, 1975 , vol. 97, p. 6484 - 6491
反应条件
in diethyl ether T=35°C; 4 h;
参考文献
Albertola, Angel; Antolin, Luis Fernando; Gonzalez, Ana; Laguna, Miguel Angel; Pulido, Francisco Jose
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1988 , p. 791 - 794
反应条件
in diethyl ether T=35°C; 2 h;
参考文献
Albertola, Angel; Antolin, Luis Fernando; Gonzalez, Ana; Laguna, Miguel Angel; Pulido, Francisco Jose
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1988 , p. 791 - 794
反应条件
1: thionyl chloride / 70 °C 2: lithium aluminium tetrahydride / tetrahydrofuran / 0 - 20 °C 3: Dess-Martin periodane / dichloromethane / 1.17 h / 0 - 20 °C 4: tetrahydrofuran; diethyl ether / 1.67 h / 0 - 20 °C 5: pyridinium chlorochromate / dichloromethane / 1 h / 0 - 20 °C View Scheme
参考文献
TEMPERO PHARMACEUTICALS, INC.; BALOGLU, Erkan; BOHNERT, Gary, J.; GHOSH, Shomir; LOBERA, Mercedes; SCHMIDT, Darby, R.; SUNG, Leonard
Patent: WO2013/19682 A1, 2013 ;
WO 2013/019682 A1
反应条件
1: lithium aluminium tetrahydride / tetrahydrofuran / 0 - 20 °C 2: Dess-Martin periodane / dichloromethane / 1.17 h / 0 - 20 °C 3: tetrahydrofuran; diethyl ether / 1.67 h / 0 - 20 °C 4: pyridinium chlorochromate / dichloromethane / 1 h / 0 - 20 °C View Scheme
参考文献
TEMPERO PHARMACEUTICALS, INC.; BALOGLU, Erkan; BOHNERT, Gary, J.; GHOSH, Shomir; LOBERA, Mercedes; SCHMIDT, Darby, R.; SUNG, Leonard
Patent: WO2013/19682 A1, 2013 ;
WO 2013/019682 A1
反应条件
1: Dess-Martin periodane / dichloromethane / 1.17 h / 0 - 20 °C 2: tetrahydrofuran; diethyl ether / 1.67 h / 0 - 20 °C 3: pyridinium chlorochromate / dichloromethane / 1 h / 0 - 20 °C View Scheme
参考文献
TEMPERO PHARMACEUTICALS, INC.; BALOGLU, Erkan; BOHNERT, Gary, J.; GHOSH, Shomir; LOBERA, Mercedes; SCHMIDT, Darby, R.; SUNG, Leonard
Patent: WO2013/19682 A1, 2013 ;
WO 2013/019682 A1
反应条件
1: tetrahydrofuran; diethyl ether / 1.67 h / 0 - 20 °C 2: pyridinium chlorochromate / dichloromethane / 1 h / 0 - 20 °C View Scheme
参考文献
TEMPERO PHARMACEUTICALS, INC.; BALOGLU, Erkan; BOHNERT, Gary, J.; GHOSH, Shomir; LOBERA, Mercedes; SCHMIDT, Darby, R.; SUNG, Leonard
Patent: WO2013/19682 A1, 2013 ;
WO 2013/019682 A1
反应条件
1.1: pyridine / dichloromethane / 20 °C 1.2: 1 h / 20 °C 2.1: tetrahydrofuran / 4 h / 0 - 20 °C 2.2: 1 h / 20 °C View Scheme
参考文献
SANOFI; EL-AHMAD, Youssef; FILOCHE-ROMME, Bruno; GANZHORM, Axel; MARCINIAK, Gilbert; MUZET, Nicolas; RONAN, Baptiste; VIVET, Bertrand; ZERR, Véronique
Patent: WO2013/190123 A1, 2013 ;
