反应条件
1.1: diisopropylamine; n-butyllithium / tetrahydrofuran; hexane / -78 - 20 °C 2.1: lithium aluminium tetrahydride / tetrahydrofuran / 72 h / 0 - 20 °C 2.2: 1 h / 0 - 20 °C 3.1: pyridine / dichloromethane / 0 - 20 °C 3.2: 1 h 4.1: lithium aluminium tetrahydride / tetrahydrofuran / 0 - 66 °C 4.2: 1 h / 0 - 20 °C 5.1: water; acetic acid / 3 h / 66 °C View Scheme
参考文献
F.HOFFMANN-LA ROCHE AG; GENENTECH, INC.; BROOKFIELD, Frederick; BURCH, Jason; GOLDSMITH, Richard A.; HU, Baihua; LAU, Kevin Hon Luen; MACKINNON, Colin H.; ORTWINE, Daniel Fred; PEI, Zhonghua; WU, Guosheng; YUEN, Po-wai; ZHANG, Yamin
Patent: WO2014/23258 A1, 2014 ;
