反应条件
1: 1.) MeSO2Cl, Et3N, 2.) LiBr / 1.) CH2Cl2, r.t., 3 h, 2.) acetone, r.t., 5 h 2: 1.) n-BuLi / 1.) THF, hexane, 0 deg C, 30 min, 2.) THF, r.t., 2 h 3: 1.) n-BuLi / 1.) THF, hexane, 0 deg C, 30 min, 2.) THF, r.t., 2 h 4: 73 percent / silica gel / tetrahydrofuran; H2O / 5 h / 25 °C 5: 22 percent / hydrazine hydrate, KOH / bis-(2-hydroxy-ethyl) ether / 3 h / Heating 6: 92 percent / 5percent aq. HCl / tetrahydrofuran / 1 h / Ambient temperature View Scheme
