(2R)-2-氨甲酰基吡咯烷-1-甲酸叔丁酯合成路线 （共 23 条）
反应条件
pyridine; di-tert-butyl dicarbonate; (NH4)2CO3 in 1,4-dioxane T=20°C; 18 h;
参考文献
Bioorganic and Medicinal Chemistry, , vol. 10, # 6 p. 1719 - 1729
反应条件
in 1,4-dioxane; water T=20°C;
参考文献
Tetrahedron Letters, , vol. 52, # 42 p. 5435 - 5437
反应条件
silica gel; ytterbium(III) triflate in neat (no solvent) T=40°C; 66 h;
参考文献
Tetrahedron Letters, , vol. 39, # 27 p. 4869 - 4870
反应条件
ammonia in ethyl acetate 16 h; Ambient temperature;
参考文献
Tetrahedron Letters, , vol. 32, # 39 p. 5359 - 5362
反应条件
ammonia in tetrahydrofuran; water T=60°C; 18 h; Inert atmosphere;
参考文献
Journal of Medicinal Chemistry, , vol. 52, # 21 p. 6672 - 6684
反应条件
1.1: sodium carbonate / 1,4-dioxane; water / 16 h / 20 °C 2.1: triethylamine; isobutyl chloroformate / dichloromethane / 1 h / 0 - 20 °C 2.2: 6 h / 20 °C View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 54, # 10 p. 3524 - 3548
反应条件
1.1: sodium carbonate / 1,4-dioxane; water / 16 h / 20 °C 2.1: triethylamine; isobutyl chloroformate / dichloromethane / 1 h / 0 - 20 °C 2.2: 6 h / 20 °C View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 54, # 10 p. 3524 - 3548
参考文献
Polish Journal of Chemistry, , vol. 60, # 1-3 p. 95 - 105
反应条件
ammonia in chloroform Ambient temperature;
参考文献
Synthetic Communications, , vol. 24, # 9 p. 1239 - 1246
反应条件
1: With triethylamine; isobutyl chloroformate in dichloromethane T=0 - 20°C; 1 h; 2: With ammonia in methanol; dichloromethane T=20°C; 6 h;
参考文献
Journal of Medicinal Chemistry, , vol. 54, # 10 p. 3524 - 3548
