5-乙酰基-2,2-噻吩基合成路线 （共 11 条）
反应条件
1: With palladium diacetate; xantphos in N-dodecane; butan-1-ol T=25°C; Suzuki-Miyaura Coupling; 1 h; Inert atmosphereGlovebox; 2: With cesium hydroxide monohydrate in N-dodecane; water; butan-1-ol T=80°C; Suzuki-Miyaura Coupling; 4 h; Inert atmosphereGlovebox;
参考文献
European Journal of Organic Chemistry, , # 31 p. 6248 - 6259,12
European Journal of Organic Chemistry, , # 31 p. 6248 - 6259
反应条件
phosphoric acid in acetic anhydride
参考文献
US5747525 A1, ;
US5753692 A1, ;
US5602170 A1, ;
反应条件
phosphoric acid T=100°C; 2 - 14 h;
参考文献
Polyhedron, , vol. 54, p. 201 - 210
反应条件
sodium carbonate; tetrakis(triphenylphosphine) palladium(0) in ethylene glycol dimethyl ether T=75°C; Suzuki-Kumada coupling; 5 h;
参考文献
Journal of the Chemical Society. Perkin Transactions 1, , # 18 p. 2090 - 2110
反应条件
1: 2-(thien-2-yl)thiophene With n-butyllithium in tetrahydrofuran T=-78 - 20°C; Inert atmosphere; 2: N,N-dimethyl acetamide in tetrahydrofuran T=20°C; 2 h;
参考文献
Canadian Journal of Chemistry, , vol. 88, # 3 p. 236 - 246
反应条件
bis-triphenylphosphine-palladium(II) chloride in tetrahydrofuran 20 h; Heating;
参考文献
Phosphorus, Sulfur and Silicon and the Related Elements, , vol. 126, p. 65 - 74
反应条件
1: thien-2-ylmagnesium bromide With bismuth(III) chloride 2: 1-(5-bromo-thien-2-yl)ethanone With potassium phosphate; palladium diacetate; triphenylphosphine in N,N-dimethyl-formamide T=90°C; 1 h; Inert atmosphere;
参考文献
Synlett, , # 9 p. 1324 - 1330
反应条件
titanium tetrachloride; acetyl chloride; benzene
参考文献
Justus Liebigs Annalen der Chemie, , vol. 543, p. 119,126
反应条件
in acetonitrile 3 h; Irradiation;
参考文献
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), , p. 1777 - 1780
反应条件
titanium tetrachloride in benzene r.t.to 80 deg C;
参考文献
Chemische Berichte, , vol. 118, # 9 p. 3714 - 3723
