3-[氨基-[二(2-氯乙基)氨基]磷酰]氧基丙醛合成路线 （共 14 条）
反应条件
1: 27 percent / ozone, 30percent aq. H2O2 / acetone; H2O / Ambient temperature 2: Ph3P / CH2Cl2 / 0.25 h / Ambient temperature View Scheme
参考文献
Zon, Gerald; Ludeman, Susan Marie; Brandt, Joan A.; Boyd, Victoria L.; Oezkan, Gunay; et al.
Journal of Medicinal Chemistry, 1984 , vol. 27, # 4 p. 466 - 485
反应条件
triphenylphosphine in dichloromethane 0.25 h; Ambient temperature; Title compound not separated from byproducts;
参考文献
Zon, Gerald; Ludeman, Susan Marie; Brandt, Joan A.; Boyd, Victoria L.; Oezkan, Gunay; et al.
Journal of Medicinal Chemistry, 1984 , vol. 27, # 4 p. 466 - 485
反应条件
Py*HClCrO3 in dichloromethane
参考文献
Myles,A. et al.
Tetrahedron Letters, 1977 , p. 2475 - 2478
反应条件
triphenylphosphine in dichloromethane T=5°C; 0.166667 h; Rate constant;
参考文献
Boyd, Victoria L.; Robbins, Joan D.; Egan, William; Ludeman, Susan M.
Journal of Medicinal Chemistry, 1986 , vol. 29, # 7 p. 1206 - 1210
反应条件
phosphate buffer (pD 7.0) in water-d2 T=25°C; also cacodylate buffer; free energy differences; Equilibrium constant;
参考文献
Borch; Hoye; Swanson
Journal of Medicinal Chemistry, 1984 , vol. 27, # 4 p. 490 - 494
反应条件
acetate bufer in water T=37°C; var. buffer conc., var. pH, var. ionic strength; Rate constantMechanism;
参考文献
Kwon, Chul-Hoon; Borch, Richard F.; Engel, Jurgen; Niemeyer, Ulf
Journal of Medicinal Chemistry, 1987 , vol. 30, # 2 p. 395 - 399
反应条件
acetate buffer in water T=37°C;
参考文献
Kwon, Chul-Hoon; Borch, Richard F.; Engel, Jurgen; Niemeyer, Ulf
Journal of Medicinal Chemistry, 1987 , vol. 30, # 2 p. 395 - 399
反应条件
2,6-dimethylpyridine T=37°C; apparent half-lives; various pH; Rate constant;
参考文献
Zon, Gerald; Ludeman, Susan Marie; Brandt, Joan A.; Boyd, Victoria L.; Oezkan, Gunay; et al.
Journal of Medicinal Chemistry, 1984 , vol. 27, # 4 p. 466 - 485
反应条件
2,6-dimethylpyridine T=37°C; apparent half-lives; various pH; Rate constant;
参考文献
Zon, Gerald; Ludeman, Susan Marie; Brandt, Joan A.; Boyd, Victoria L.; Oezkan, Gunay; et al.
Journal of Medicinal Chemistry, 1984 , vol. 27, # 4 p. 466 - 485
反应条件
lutidine buffer; sodium thiosulfate T=37°C; Product distribution;
参考文献
Zon, Gerald; Ludeman, Susan Marie; Brandt, Joan A.; Boyd, Victoria L.; Oezkan, Gunay; et al.
Journal of Medicinal Chemistry, 1984 , vol. 27, # 4 p. 466 - 485
