4-氯-2,6-二甲基吡啶合成路线 （共 33 条）
反应条件
1: With hydrogenchloride in water T=10 - 20°C; 2: With trichlorophosphate 8 h; Reflux; 3: With potassium carbonate in water T=0°C;
参考文献
EVOTEC NEUROSCIENCES GMBH
Patent: WO2009/135842 A1, 2009 ;
Location in patent: Page/Page column 81 ;
WO 2009/135842 A1
反应条件
trichlorophosphate 1 h; Inert atmosphereReflux;
参考文献
Malamas, Michael S.; Barnes, Keith; Johnson, Matthew; Hui, Yu; Zhou, Ping; Turner, Jim; Hu, Yun; Wagner, Erik; Fan, Kristi; Chopra, Rajiv; Olland, Andrea; Bard, Jonathan; Pangalos, Menelas; Reinhart, Peter; Robichaud, Albert J.
Bioorganic and Medicinal Chemistry, 2010 , vol. 18, # 2 p. 630 - 639
反应条件
copper dichloride in methanol T=90°C;
参考文献
Murphy, Jaclyn M.; Liao, Xuebin; Hartwig, John F.
Journal of the American Chemical Society, 2007 , vol. 129, # 50 p. 15434 - 15435
反应条件
phosphorus trichoride in chloroform
参考文献
Yoakim; Bonneau; Deziel; Doyon; Duan; Guse; Landry; Malenfant; Naud; Ogilvie; O'Meara; Plante; Simoneau; Thavonekham; Boes; Cordingley
Bioorganic and Medicinal Chemistry Letters, 2004 , vol. 14, # 3 p. 739 - 742
反应条件
1: 85 percent / mCPBA / CH2Cl2 2: 59 percent / HNO3; H2SO4 / 80 °C 3: 86 percent / aq. HCl / 200 °C 4: 100 percent / PCl3 / CHCl3 View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 14, # 3 p. 739 - 742
反应条件
1: 86 percent / aq. HCl / 200 °C 2: 100 percent / PCl3 / CHCl3 View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 14, # 3 p. 739 - 742
反应条件
trichlorophosphate T=150°C;
参考文献
Yakugaku Zasshi, , vol. 71, p. 217,218
Chem.Abstr., , p. 4541
Yakugaku Zasshi, , vol. 75, p. 1233
Chem.Abstr., , p. 8664
反应条件
phosphorus pentachloride; trichlorophosphate T=140°C;
参考文献
Chemische Berichte, , vol. 20, p. 164
反应条件
hydrogenchloride; HNO2
参考文献
Chemische Berichte, , vol. 27, p. 1323
