4-溴-2,3,5,6-四氟吡啶合成路线 （共 15 条）
参考文献
Platonov; Maksimov; Dvornikova; Nikul'shin
Russian Journal of Organic Chemistry, 2005 , vol. 41, # 11 p. 1647 - 1653
反应条件
in not given molar ratio CaBr2/C5F5N = 3.8/1, 4 h;;
参考文献
Gmelin Handbook: F: PerFHalOrg.5, 4, page 115 - 148
反应条件
1: neat (no solvent) 2: sulfolane View Scheme
参考文献
F: PerFHalOrg.5, 4, page 115 - 148
反应条件
2: steel wool / neat (no solvent) 3: sulfolane View Scheme
参考文献
F: PerFHalOrg.5, 4, page 115 - 148
反应条件
in hydrogen fluoride; hydrogen bromide Diazotation with NaNO2 in 20 percent aq. HF at - 20 °C (0.5 h). Cleavage by dropwise addn. of CuBr in 48 percent aq. HBr at -20 to -25 °C (0.5 h).;
参考文献
Gmelin Handbook: F: PerFHalOrg.5, 4, page 115 - 148
反应条件
1: With tin(ll) chloride; zinc in N,N-dimethyl-formamide Metallation; sonication; 2: With bromine in N,N-dimethyl-formamide Substitution; 1 h;
参考文献
Tetrahedron Letters, , vol. 41, # 20 p. 3817 - 3819
反应条件
in sulfolane C5F5N, dissolved in sulfolane, reacts with HBr at 100 °C (20 h), then at 130-160 °C (148 h).;
参考文献
Journal of the Chemical Society [Section] C: Organic, , p. 61 - 67
反应条件
1: neat (no solvent, gas phase) 2: neat (no solvent) 3: sulfolane View Scheme
参考文献
F: PerFHalOrg.5, 4, page 115 - 148
反应条件
1: neat (no solvent) 2: sulfolane View Scheme
参考文献
F: PerFHalOrg.5, 4, page 115 - 148
反应条件
in not given good yields for 4-Br-C5F4N and 2,4,6-Br3-C5F2N, traces of 2,4-Br2C5F3N;;
参考文献
Chemistry and Industry (London, United Kingdom), , p. 943 - 947
