2-(3-氯苯基)-3-甲基-4-喹啉羧酸合成路线 (共 1 条)
反应条件
1: indole-2,3-dione With potassium hydroxide in ethanol; water 0.25 h; 2: 3'-chloropropiophenone in ethanol; water 18 h; Reflux; 3: With hydrogenchloride in water Cooling with ice;
参考文献
GLAXOSMITHKLINE LLC; BROOKS, Carl, A.; CHEUNG, Mui; EIDAM, Hilary, S.; FOX, Ryan, M; HILFKER, Mark, A.; MANAS, Eric, S.; YE, Guosen
Patent: WO2011/119704 A1, 2011 ;
Location in patent: Page/Page column 54 ;