3-(4-氯苯基)-2-丙烯酰氯合成路线 （共 15 条）
反应条件
1: triethylamine / CHCl3
2: POCl3 / 0.5 h / 100 - 110 °C
3: 89.8 percent / 2N NaOH / ethanol / 0.25 h / 90 deg C bath
4: SOCl2 / 1 h / Heating
5: NaBH4, 2N HCl / 1,2-dimethoxy-ethane / ice cooling 30 min, reflux 30 min
View Scheme
参考文献
Meguro; Tawada; Sugiyama; Fujita; Kawamatsu
Chemical and Pharmaceutical Bulletin, 1986 , vol. 34, # 7 p. 2840 - 2851
反应条件
1: triethylamine / CHCl3
2: POCl3 / 0.5 h / 100 - 110 °C
3: 89.8 percent / 2N NaOH / ethanol / 0.25 h / 90 deg C bath
4: SOCl2 / 1 h / Heating
5: NaBH4, 2N HCl / 1,2-dimethoxy-ethane / ice cooling 30 min, reflux 30 min
6: 92.8 percent / SOCl2 / 0.5 h / Ambient temperature
View Scheme
参考文献
Meguro; Tawada; Sugiyama; Fujita; Kawamatsu
Chemical and Pharmaceutical Bulletin, 1986 , vol. 34, # 7 p. 2840 - 2851
反应条件
1: 91 percent / triethylamine / CH2Cl2 / Ambient temperature
2: 89 percent / H2 / 10percent Pd/C / tetrahydrofuran / 2 h / 1810.02 Torr
3: 83 percent / KOH / aq. ethanol / 5 h / Heating
View Scheme
参考文献
Albright; DeVries; Largis; Miner; Reich; Schaffer; Shepherd; Upeslacis
Journal of Medicinal Chemistry, 1983 , vol. 26, # 10 p. 1378 - 1393
反应条件
1: 91 percent / triethylamine / CH2Cl2 / Ambient temperature
2: 89 percent / H2 / 10percent Pd/C / tetrahydrofuran / 2 h / 1810.02 Torr
3: 68 percent / diborane / tetrahydrofuran / a) RT, 1 h, b) reflux, 90 min
View Scheme
参考文献
Albright; DeVries; Largis; Miner; Reich; Schaffer; Shepherd; Upeslacis
Journal of Medicinal Chemistry, 1983 , vol. 26, # 10 p. 1378 - 1393
反应条件
1: 91 percent / triethylamine / CH2Cl2 / Ambient temperature
2: 89 percent / H2 / 10percent Pd/C / tetrahydrofuran / 2 h / 1810.02 Torr
3: 68 percent / diborane / tetrahydrofuran / a) RT, 1 h, b) reflux, 90 min
4: 97 percent / KOH / aq. ethanol / 5 h / Heating
View Scheme
参考文献
Albright; DeVries; Largis; Miner; Reich; Schaffer; Shepherd; Upeslacis
Journal of Medicinal Chemistry, 1983 , vol. 26, # 10 p. 1378 - 1393
