3-(4-氯苯基)-2-丙烯酰氯合成路线 （共 15 条）
反应条件
thionyl chloride Heating;
参考文献
Sharma; Kaur, Sukhvir
Journal of the Indian Chemical Society, 2007 , vol. 84, # 6 p. 612 - 614
反应条件
1: piperidine / 3 h / |Reflux 2: triethylamine; 2,4,6-trichloro-1,3,5-triazine / acetonitrile / 1 h / 20 °C View Scheme
参考文献
Zhu, Jun; Majikina, Motoji; Tawata, Shinkichi
Bioscience, Biotechnology and Biochemistry, 2001 , vol. 65, # 1 p. 161 - 163
反应条件
1: 100 percent / aq. Na2CO3 / CH2Cl2 / Ambient temperature 2: 87 percent / POCl3 / toluene / Ambient temperature 3: CH2Cl2; toluene / 46 h / Ambient temperature 4: 80 percent / NiCl2*6H2O, NaBH4 / tetrahydrofuran; H2O / 0.42 h / Ambient temperature 5: 96 percent / 2N aq. NaOH, EtOH / 14 h / 100 °C View Scheme
参考文献
Langlois, Nicole; Dahuron, Nathalie; Wang, Hai-Shan
Tetrahedron, 1996 , vol. 52, # 48 p. 15117 - 15126
反应条件
T=25°C; kinetic isotope effect; var. solvents; Rate constant;
参考文献
Kim, Tae-Hyoung; Huh, Chul; Lee, Bon-Su; Lee, Ikchoon
Journal of the Chemical Society, Perkin Transactions 2: Physical Organic Chemistry (1972-1999), 1995 , # 12 p. 2257 - 2262
参考文献
Rondestvedt; Ver Nooy
Journal of the American Chemical Society, 1955 , vol. 77, p. 4878,4881, 4882
反应条件
sodium hydride in tetrahydrofuran 1.) 0 deg C, 30 min, 2.) -78 deg C to r.t.;
参考文献
Laxmi, Yennu Santosh; Iyengar, Divi Sarangapani
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1995 , # 23 p. 3043 - 3046
反应条件
1: aq. NH3 / diethyl ether / 18.5 h
2: LiAlH4 / tetrahydrofuran / 5 h
View Scheme
参考文献
Fujimura, Ken-Ichi; Matsumoto, Junzo; Niwa, Masashi; Kobayashi, Tadayuki; Kawashima, Yoichi; In, Yasuko; Ishida, Toshimasa
Bioorganic and Medicinal Chemistry, 1997 , vol. 5, # 8 p. 1675 - 1683
反应条件
triethylamine; triphenylphosphine; palladium dichloride in 1,4-dioxane
T=80°C; 4 h;
参考文献
Rao, Maddali L.N.; Venkatesh, Varadhachari; Jadhav, Deepak N.
Journal of Organometallic Chemistry, 2008 , vol. 693, # 15 p. 2494 - 2498
反应条件
1: 91 percent / triethylamine / CH2Cl2 / Ambient temperature
2: 89 percent / H2 / 10percent Pd/C / tetrahydrofuran / 2 h / 1810.02 Torr
3: 68 percent / diborane / tetrahydrofuran / a) RT, 1 h, b) reflux, 90 min
4: 78 percent / CH2Cl2 / Ambient temperature
5: 74 percent / KOH / aq. ethanol / 5 h / Heating
View Scheme
参考文献
Albright; DeVries; Largis; Miner; Reich; Schaffer; Shepherd; Upeslacis
Journal of Medicinal Chemistry, 1983 , vol. 26, # 10 p. 1378 - 1393
反应条件
1: triethylamine / CHCl3
2: POCl3 / 0.5 h / 100 - 110 °C
3: 89.8 percent / 2N NaOH / ethanol / 0.25 h / 90 deg C bath
View Scheme
参考文献
Meguro; Tawada; Sugiyama; Fujita; Kawamatsu
Chemical and Pharmaceutical Bulletin, 1986 , vol. 34, # 7 p. 2840 - 2851
