3-二甲基氨基-1-苯丙烷-1-酮合成路线 （共 69 条）
反应条件
1: diethyl ether
2: aqueous hydrochloric acid; acetic acid
3: palladium; ethanol / Hydrogenation
View Scheme
参考文献
Adamson et al.
Journal of the Chemical Society, 1949 , p. Spl. 144, 152
反应条件
1: diethyl ether
2: chloroform; thionyl chloride
3: ethanol
4: diethyl ether / anschliessendes Behandeln mit wss. Salzsaeure
View Scheme
参考文献
Kawabata; Nitta; Kasai
Yakugaku Zasshi, 1949 , vol. 69, p. 190
Chem.Abstr., 1950 , p. 1451
反应条件
1: palladium/barium sulfate / 120 °C / Hydrogenation
View Scheme
参考文献
Reichert; Posemann
Archiv der Pharmazie (Weinheim, Germany), 1943 , vol. 281, p. 189
反应条件
sodium tetrahydroborate in water
T=0 - 20°C;
参考文献
Kellogg, Richard M.; Nieuwenhuijzen, Jose W.; Pouwer; Vries, Ton R.; Broxterman, Quirinus B.; Grimbergen, Reinier F.P.; Kaptein, Bernard; La Crois, Rene M.; De Wever, Ellen; Zwaagstra, Karen; Van Der Laan, Alexander C.
Synthesis, 2003 , # 10 p. 1626 - 1638
参考文献
Mannich; Heilner
Chemische Berichte, 1922 , vol. 55, p. 362
反应条件
anhydrous butyl ether
参考文献
Denton et al.
Journal of the American Chemical Society, 1949 , vol. 71, p. 2050,2052
Journal of the American Chemical Society, 1950 , vol. 72, p. 3795
反应条件
1: diethyl ether; benzene
2: NaI / 264 h / Heating
View Scheme
参考文献
Trachtenberg,E.N.; Whall,T.J.
Journal of Organic Chemistry, 1972 , vol. 37, p. 1494 - 1499
反应条件
1: tetrahydrofuran / 2.5 h / 0 °C
2: benzene / 3 h / Heating
3: H2 / 10 percent Pd/C / methanol / 12 h / 20 °C
View Scheme
参考文献
Selvamurugan; Aidhen
Synthesis, 2001 , # 15 p. 2239 - 2246
反应条件
in ethanol
T=20°C; 18 h;
参考文献
ELI LILLY AND COMPANY
Patent: WO2004/26305 A1, 2004 ;
Location in patent: Page/Page column 70-71 ;
WO 2004/026305 A1
反应条件
N-benzyl-trimethylammonium hydroxide in methanol
1.) reflux, 220 min; 2.) RT, 12 h;
参考文献
Guarna, Antonio; Occhiato, Ernesto G.; Spinetti, Laura M.; Vallecchi, Maria E.; Scarpi, Dina
Tetrahedron, 1995 , vol. 51, # 6 p. 1775 - 1788
