3-二甲基氨基-1-苯丙烷-1-酮合成路线 （共 69 条）
反应条件
1: With trifluorormethanesulfonic acid in dichloromethane T=60 - 80°C; Houben-Housch synthesis; Inert atmosphere; 2: With water in dichloromethane Houben-Housch synthesis; Inert atmosphereCooling with ice; 3: With sodium hydroxide in water Inert atmosphere;
参考文献
Raja, Erum K.; Klumpp, Douglas A.
Tetrahedron, 2011 , vol. 67, # 25 p. 4494 - 4497
反应条件
hydrogenchloride in ethanol 2 h; Heating;
参考文献
Kellogg, Richard M.; Nieuwenhuijzen, Jose W.; Pouwer; Vries, Ton R.; Broxterman, Quirinus B.; Grimbergen, Reinier F.P.; Kaptein, Bernard; La Crois, Rene M.; De Wever, Ellen; Zwaagstra, Karen; Van Der Laan, Alexander C.
Synthesis, 2003 , # 10 p. 1626 - 1638
反应条件
hydrogenchloride in water; isopropyl alcohol T=100°C; Sealed tubeInert atmosphereGreen chemistry;
参考文献
Wang, Jiahao; Liu, Delong; Liu, Yangang; Zhang, Wanbin
Organic and Biomolecular Chemistry, 2013 , vol. 11, # 23 p. 3855 - 3861
参考文献
VITAE PHARMACEUTICALS, INC.
Patent: WO2009/17664 A1, 2009 ;
Location in patent: Page/Page column 148 ;
WO 2009/017664 A1
反应条件
hydrogen; platinum(IV) oxide in acetic acid P=2280 Torr; 4 h;
参考文献
San Martin; De Marigorta; Dominguez
Tetrahedron, 1994 , vol. 50, # 7 p. 2255 - 2264
反应条件
sodium hydroxide in water T=0 - 5°C; pH=10;
参考文献
Surya Prakash Rao; Jeyalakshmi; Senthilkumar
Tetrahedron, 2002 , vol. 58, # 11 p. 2189 - 2199
反应条件
1: bromobenzene With magnesium in tetrahydrofuran 1 h; Heating; 2: 3-dimethylamino-N-methoxy-N-methyl-propionamide in tetrahydrofuran T=0°C;
参考文献
Selvamurugan; Aidhen
Synthesis, 2001 , # 15 p. 2239 - 2246
反应条件
hydrogenchloride in ethanol; water 3 h; Heating / reflux;
参考文献
WO2006/113837 A2, ;
Page/Page column 139 ;
WO 2006/113837 A2
反应条件
copper(l) iodide; lithium aluminium tetrahydride in tetrahydrofuran T=0°C;
参考文献
Tetrahedron, , vol. 50, # 7 p. 2255 - 2264
反应条件
1: Et3N / dimethylformamide / Heating 2: 1.) chloroiodomethane / dimethylsulfoxide / 3 h / Ambient temperature View Scheme
参考文献
Bulletin of the Chemical Society of Japan, , vol. 55, # 2 p. 534 - 539
