(S)-2-溴-3-苯基丙酸合成路线 （共 11 条）
反应条件
sulfuric acid; hydrogen bromide; sodium nitrite in water
参考文献
Merrell Dow Pharmaceuticals Inc.
Patent: US5238932 A1, 1993 ;
反应条件
hydrogen bromide; sodium nitrite T=0°C; 2 h;
参考文献
Coric, Pascale; Turcaud, Serge; Meudal, Herve; Roques, Bernard Pierre; Fournie-Zaluski, Marie-Claude
Journal of Medicinal Chemistry, 1996 , vol. 39, # 6 p. 1210 - 1219
反应条件
D-glucose in ethanol; water T=30°C; 72 h; Microbiological reaction; optical yield given as percent eeenantioselective reaction;
参考文献
Brenna, Elisabetta; Gatti, Francesco G.; Manfredi, Alessia; Monti, Daniela; Parmeggiani, Fabio
European Journal of Organic Chemistry, 2011 , # 20-21 p. 4015 - 4022
反应条件
hydrogen bromide; sodium nitrite in water; toluene T=-5 - 15°C; 6 h; Title compound not separated from byproducts;
参考文献
Organic Letters, , vol. 6, # 19 p. 3233 - 3235
反应条件
1.1: Inert atmosphere 2.1: tetrahydrofuran; N,N'-dimethyl-N,N'-propyleneurea; indium(III) chloride; indium; chloro-trimethyl-silane; triethylamine / 10 - 30 °C / Inert atmosphere; Sonication 2.2: Saturated solution View Scheme
参考文献
Ishihara, Jun; Watanabe, Yuki; Koyama, Noriko; Nishino, Yukihiro; Takahashi, Keisuke; Hatakeyama, Susumi
Tetrahedron, 2011 , vol. 67, # 20 p. 3659 - 3667
反应条件
water; sodium carbonate 4 h; Reflux;
参考文献
Rochon, Kristina; Proteau-Gagne, Arnaud; Bourassa, Philippe; Nadon, Jean-Francois; Coite, Jerome; Bournival, Veronique; Gobeil, Fernand; Guerin, Brigitte; Dory, Yves L.; Gendron, Louis
ACS Chemical Neuroscience, 2013 , vol. 4, # 8 p. 1204 - 1216
反应条件
1: 94 percent / sulfuric acid / 1 h / Heating 2: 74 percent / zinc; dibromoethane / various solvent(s) / 1.5 h / 20 °C 3: Pd/C; ammonium formate / tetrahydrofuran; methanol / 20 °C 4: LiOH / H2O View Scheme
参考文献
Moumne, Roba; Lavielle, Solange; Karoyan, Philippe
Journal of Organic Chemistry, 2006 , vol. 71, # 8 p. 3332 - 3334
反应条件
2: 1.) hemin copolymer 1, sodium azide / 1.) water, 12 h, 2.) benzene, 6 h, 60 deg C 3: hydrogen / Pd/C View Scheme
参考文献
Saito, Kiyoshi; Harada, Kaoru
Bulletin of the Chemical Society of Japan, 1989 , vol. 62, # 8 p. 2562 - 2566
反应条件
in N,N-dimethyl-formamide Ambient temperature;
参考文献
Coric, Pascale; Turcaud, Serge; Meudal, Herve; Roques, Bernard Pierre; Fournie-Zaluski, Marie-Claude
Journal of Medicinal Chemistry, 1996 , vol. 39, # 6 p. 1210 - 1219
反应条件
in methanol 12 h; Ambient temperature;
参考文献
Spaltenstein; Leban; Furfine
Tetrahedron Letters, 1993 , vol. 34, # 9 p. 1457 - 1460
