苄氧羰基-脯氨酰-甘氨酰胺合成路线 （共 4 条）
反应条件
4-(N,N-dimethlyamino)pyridine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride in dichloromethane T=20°C;
参考文献
SMITHKLINE BEECHAM CORPORATION
Patent: WO2007/67906 A2, 2007 ;
Location in patent: Page/Page column 24-25 ;
反应条件
ammonia in methanol 24 h; Ambient temperature;
参考文献
Burov, S. V.; Kaurov, O. A.; Martynov, V. F.; Smirnova, M. P.
Chemistry of Natural Compounds, 1980 , vol. 16, # 5 p. 518 - 524
Khimiya Prirodnykh Soedinenii, 1980 , vol. 16, # 5 p. 706 - 714
反应条件
1: 1) Ammonia, 2) 1,2,4-triazole / 1) Chloroform, 10 min, room temperature, 2) ethyl acetate, 1 h, room temperature. 2: 94 percent / Ammonia / methanol / 24 h / Ambient temperature View Scheme
参考文献
Nikolaev, S. V.; Martinov, V. F.
Chemistry of Natural Compounds, 1985 , vol. 21, # 2 p. 269 - 270
Khimiya Prirodnykh Soedinenii, 1985 , # 2 p. 281 - 282
反应条件
1: H(1+)
3: hydrogen bromide / acetic acid
5: H2 / catalytic hydrog.
View Scheme
参考文献
Nikolaev, S. V.; Martinov, V. F.
Chemistry of Natural Compounds, 1985 , vol. 21, # 2 p. 269 - 270
Khimiya Prirodnykh Soedinenii, 1985 , # 2 p. 281 - 282
