1,1,1-三氟-3-苯基丙酮合成路线 （共 31 条）
反应条件
1.1: 82 percent / phosphorus oxychloride / 20 h / 70 °C
2.1: NaH / tetrahydrofuran / 25 °C
2.2: 78 percent / tetrahydrofuran / 20 h / 20 °C
3.1: 93 percent / aq. NaOH / ethanol / 0.5 h / 20 °C
4.1: 98 percent / BH3*THF / tetrahydrofuran / 3 h / Heating
5.1: 60 percent / PPh3; diethylazodicarboxylate / tetrahydrofuran / 2 h / 20 °C
View Scheme
参考文献
Hale, Jeffrey J.; Lynch, Christopher L.; Neway, William; Mills, Sander G.; Hajdu, Richard; Keohane, Carol Ann; Rosenbach, Mark J.; Milligan, James A.; Shei, Gan-Ju; Parent, Stephen A.; Chrebet, Gary; Bergstrom, James; Card, Deborah; Ferrer, Marc; Hodder, Peter; Strulovici, Berta; Rosen, Hugh; Mandala, Suzanne
Journal of Medicinal Chemistry, 2004 , vol. 47, # 27 p. 6662 - 6665
