1-(甲苯-4-磺酰基)-1H-吡咯并[2,3-b]吡啶合成路线 （共 6 条）
反应条件
1: 1H-Pyrrolo[2,3-b]pyridine With sodium hydride in tetrahydrofuran; mineral oil T=0 - 23°C; Inert atmosphere; 2: p-toluenesulfonyl chloride in tetrahydrofuran; mineral oil T=0 - 23°C; Inert atmosphere;
参考文献
Yamaguchi, Atsushi D.; Mandal, Debashis; Yamaguchi, Junichiro; Itami, Kenichiro
Chemistry Letters, 2011 , vol. 40, # 6 p. 555 - 557
反应条件
N-ethyl-N,N-diisopropylamine T=90°C; 2 h; Inert atmosphereNeat (no solvent);
参考文献
Keith, John M.
Journal of Organic Chemistry, 2010 , vol. 75, # 8 p. 2722 - 2725
反应条件
1: 1-tosyl-1H-pyrrolo[2,3-b]pyridine With n-butyllithium in tetrahydrofuran; hexane T=-70°C; 0.5 h; Cooling with acetone-dry iceInert atmosphere; 2: methyl iodide in tetrahydrofuran; hexane T=-70°C; 3 h; Inert atmosphere;
参考文献
sanofi-aventis
Patent: US2009/253679 A1, 2009 ;
Location in patent: Page/Page column 37 ;
反应条件
1: With n-butyllithium in tetrahydrofuran; hexane T=-78°C; 0.833333 h; 2: With iodine in tetrahydrofuran; 1,2,2-trichloro-1,1,2-trichloro-ethane T=20°C;
参考文献
Nemecek, Conception; Metz, William A.; Wentzler, Sylvie; Ding, Fa-Xiang; Venot, Corinne; Souaille, Catherine; Dagallier, Anne; Maignan, Sebastien; Guilloteau, Jean-Pierre; Bernard, Francois; Henry, Alain; Grapinet, Sandrine; Lesuisse, Dominique
Chemical Biology and Drug Design, 2010 , vol. 76, # 2 p. 100 - 106
反应条件
1: n-butyllithium; iodine / tetrahydrofuran 2: tetrakis(triphenylphosphine) palladium(0); sodium hydrogencarbonate / water; N,N-dimethyl-formamide / 110 °C View Scheme
参考文献
Nemecek, Conception; Metz, William A.; Wentzler, Sylvie; Ding, Fa-Xiang; Venot, Corinne; Souaille, Catherine; Dagallier, Anne; Maignan, Sebastien; Guilloteau, Jean-Pierre; Bernard, Francois; Henry, Alain; Grapinet, Sandrine; Lesuisse, Dominique
Chemical Biology and Drug Design, 2010 , vol. 76, # 2 p. 100 - 106
反应条件
1: With n-butyllithium in tetrahydrofuran; hexane T=-78°C; 1.33333 h; 2: With 1,2-dibromo-1,1,2,2-tetrachloroethane in tetrahydrofuran; hexane T=-78 - 20°C;
参考文献
INTERMUNE, INC.
Patent: US2009/318455 A1, 2009 ;
Location in patent: Page/Page column 98-99 ;
