2-(4-甲酰基苯基)乙酸合成路线 （共 12 条）
反应条件
1: With methanol; sodium hydroxide; water T=20°C; 16 h; 2: With hydrogenchloride in water pH=1;
参考文献
Ji, Yu-Hua; Mammen, Mathai; Husfeld, Craig; Li, Li; Mu, YongQi; Kushner, Aaron; Stangeland, Eric; Mischki, Trevor; Hughes, Adam; Dunham, Sarah
Patent: US2006/281740 A1, 2006 ;
Location in patent: Page/Page column 37 ;
US 20060281740 A1
反应条件
manganese(IV) oxide in chloroform T=50°C; 18 h;
参考文献
CHROMA THERAPEUTICS LTD.
Patent: WO2008/40934 A1, 2008 ;
Location in patent: Page/Page column 72-73 ;
WO 2008/040934 A1
反应条件
hydrogenchloride; 1,3,5,7-tetra-azatricyclo[5.1.1.13,5]decane in ethanol; water
参考文献
CHIESI FARMACEUTICI S.p.A; ARMANI, Elisabetta; Amari, Gabriele; Riccaboni, Mauro; Baker-Glenn, Charles
Patent: US2014/155428 A1, 2014 ;
Location in patent: Page/Page column ;
反应条件
1: With diisobutylaluminium hydride in tetrahydrofuran; hexane T=-78°C; 2 h; 2: With methanol in tetrahydrofuran; hexane T=20°C;
参考文献
DAIICHI PHARMACEUTICAL CO., LTD.
Patent: EP1612204 A1, 2006 ;
Location in patent: Page/Page column 46 ;
反应条件
1: With 1,3,5,7-tetra-azatricyclo[5.1.1.13,5]decane in ethanol; water 4 h; Reflux; 2: With hydrogenchloride in ethanol; water 0.5 h; Reflux;
参考文献
Del Amo, Vicente; Slawin, Alexandra M. Z.; Philp, Douglas
Organic Letters, 2008 , vol. 10, # 20 p. 4589 - 4592
反应条件
4-(N,N-dimethlyamino)pyridine in N,N-dimethyl-formamide
参考文献
CHIESI FARMACEUTICI S.p.A; ARMANI, Elisabetta; Amari, Gabriele; Riccaboni, Mauro; Baker-Glenn, Charles
Patent: US2014/155428 A1, 2014 ;
Location in patent: Page/Page column ;
反应条件
hydrogenchloride; tert.-butyl lithium; acetic acid; phenyllithium in cyclohexane; ethyl acetate; N,N-dimethyl-formamide
参考文献
Bristol-Myers Squibb Company
Patent: US6214852 B1, 2001 ;
US 6214852 B1
反应条件
hydrogenchloride; sodium hydroxide; sodium periodate in 1,4-dioxane; water; ethyl acetate
参考文献
Bristol-Myers Squibb Company
Patent: US6214852 B1, 2001 ;
US 6214852 B1
反应条件
1: 1,3,5,7-tetra-azatricyclo[5.1.1.13,5]decane; N-bromosuccinmide; hydrogenchloride / water; ethanol; chloroform 2: 4-(N,N-dimethlyamino)pyridine / N,N-dimethyl-formamide View Scheme
参考文献
CHIESI FARMACEUTICI S.p.A; ARMANI, Elisabetta; Amari, Gabriele; Riccaboni, Mauro; Baker-Glenn, Charles
Patent: US2014/155428 A1, 2014 ;
参考文献
Baker et al.
Journal of the Chemical Society, 1956 , p. 404,410
